IMP321

A T-cell immunostimulatory factor, derived from the soluble form of the lymphocyte-activation gene 3 (LAG-3) protein, with potential antineoplastic… (More)

Topic mentions per year

Topic mentions per year

2006-2015
012320062015

Papers overview

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2016
2016
PURPOSE Cancer vaccines aim to generate and maintain antitumor immune responses. We designed a phase I/IIa clinical trial to test… (More)
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2013
2013
Immunotherapy offers a promising novel approach for the treatment of cancer and both adoptive T-cell transfer and immune… (More)
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2012
2012
Purpose This phase I study was conducted to determine the safety profile and maximum tolerated dose (MTD) of IMP321, a soluble… (More)
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2010
2010
IMP321 is a recombinant soluble LAG-3Ig fusion protein that binds to MHC class II with high avidity and mediates APC and then… (More)
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2009
2009
PURPOSE To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of IMP321, a recombinant soluble LAG-3Ig… (More)
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2009
2009
Purpose: Toevaluate the safety, tolerability, pharmacokinetics, andpharmacodynamics of IMP321, a recombinant soluble LAG-3Ig… (More)
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2007
2007
The principal antitumor immune response is mediated through the activation of type 1 cytotoxic (Tc1) CD8 T cells, NK cells, and… (More)
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2007
2007
sLAG-3 (IMP321), a natural high affinity ligand for MHC class II, was tested for safety, tolerability and its ability to increase… (More)
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2007
2007
BACKGROUND LAG-3 (CD223) is a natural high affinity ligand for MHC class II. The soluble form (sLAG-3) induces maturation of… (More)
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2006
2006
A soluble LAG-3 (CD223) molecule (sLAG-3) is a natural high affinity ligand for MHC class II. It is known to induce maturation of… (More)
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