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IKZF2 gene

Known as: IKZF2, Helios, IKAROS family zinc finger 2 
This gene is involved in both transcription and lymphocyte development.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND A number of heritable immune dysregulatory diseases result from defects affecting regulatory T (Treg) cell development… Expand
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Highly Cited
2013
Highly Cited
2013
The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL characterized by aneuploidy and poor… Expand
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Highly Cited
2012
Highly Cited
2012
The transcription factor Helios has been reported to be a marker of regulatory T cells (Treg) of thymic origin, distinguishing… Expand
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Highly Cited
2012
Highly Cited
2012
IntroductionMesenchymal stem cells (MSCs) are adult, multipotent, stem cells with immunomodulatory properties. The mechanisms… Expand
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Highly Cited
2012
Highly Cited
2012
Foxp3(+) regulatory T cells (Tregs) maintain self-tolerance and adoptive therapy, and using Foxp3(+) Tregs has been proposed as… Expand
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Highly Cited
2011
Highly Cited
2011
Regulatory T cells (Tregs) constitute an attractive therapeutic target given their essential role in controlling autoimmunity… Expand
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Highly Cited
2011
Highly Cited
2011
Monoclonal anti-CD3 Abs have been used clinically for two decades to reverse steroid-resistant acute graft rejection. In… Expand
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Highly Cited
2011
Highly Cited
2011
Foxp3+ T-regulatory cells (Tregs) normally serve to attenuate immune responses and are key to maintenance of immune homeostasis… Expand
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Highly Cited
2010
Highly Cited
2010
Helios, a member of the Ikaros transcription factor family, is preferentially expressed at the mRNA level by regulatory T cells… Expand
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Highly Cited
2006
Highly Cited
2006
Naturally occurring CD25(+)CD4(+) regulatory T cells (Tregs) actively engage in the maintenance of immunologic self-tolerance and… Expand
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