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IDUA gene

Known as: IDURONIDASE, ALPHA-L, IDUA, ALPHA-L-IDURONIDASE 
This gene plays a role in glycosaminoglycan metabolism.
National Institutes of Health

Related topics

Related topics

3 relations
Carbohydrate MetabolismHydrolysisL-Iduronidase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Enzyme replacement therapy started at birth improves outcome in difficult-to-treat organs in mucopolysaccharidosis I mice.
Highly Cited
2012
Highly Cited
2012
The designer aminoglycoside NB84 significantly reduces glycosaminoglycan accumulation associated with MPS I-H in the Idua-W392X mouse.
Highly Cited
2011
Highly Cited
2011
Reversal of lysosomal storage in brain of adult MPS-I mice with intravenous Trojan horse-iduronidase fusion protein.
A mouse model of mucopolysaccharidosis (MPS) type I, which is null for the lysosomal enzyme, α-L-iduronidase (IDUA), is treated… 
Highly Cited
2010
Highly Cited
2010
Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation.
Highly Cited
2008
Highly Cited
2008
Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood‐brain barrier
Mucopolysaccharidosis Type I, Hurler's Syndrome, is a lysosomal storage disorder that affects the brain. The missing enzyme, α‐L… 
Highly Cited
2005
Highly Cited
2005
Gene therapy for a mucopolysaccharidosis type I murine model with lentiviral-IDUA vector.
Mucopolysaccharidosis type I is a lysosomal disease due to mutations in the IDUA gene, resulting in deficiency of alpha-L… 
1999
1999
Identification and characterization of the molecular lesion causing mucopolysaccharidosis type I in cats.
Mucopolysaccharidosis Type I (MPS I) is the lysosomal storage disease caused by the deficient activity of alpha-L-iduronidase… 
1998
1998
Identifying the Source of Mean and Volatility Spillovers in Irish Equities: A Multivariate GARCH Analysis*
This paper, using a multivariate VAR-GARCH analysis, examines the role of the UK stock market in the price behaviour of the ten… 
1996
1996
Mapping Disease Risk Estimates Based on Small Numbers: An Assessment of Empirical Bayes Techniques*
Choropleth maps are frequently used to analyse spatial variations in the risk of a disease. In such maps the relative risk is… 
Highly Cited
1994
Highly Cited
1994
The gene for achondroplasia maps to the telomeric region of chromosome 4p
Achondroplasia is the most common type of genetic dwarfism. It is characterized by disproportionate short stature and other… 
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