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IDN 1965

Known as: IDN-1965, IDN1965 
 
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Pyrrolizidine alkaloids enhance alcohol-induced hepatocytotoxicity in vitro in normal human hepatocytes.
OBJECTIVE Herbal remedies containing pyrrilidozine alkaloids (PA)s can induce liver damage, including hepato-sinusoidal… Expand
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Highly Cited
2003
Highly Cited
2003
The caspase inhibitor IDN‐6556 prevents caspase activation and apoptosis in sinusoidal endothelial cells during liver preservation injury
Cold ischemia (CI)–warm reperfusion (WR) liver injury remains a problem in liver transplantation. CI‐WR initially causes… Expand
Highly Cited
2003
Highly Cited
2003
Inhibition of Cardiac Myocyte Apoptosis Improves Cardiac Function and Abolishes Mortality in the Peripartum Cardiomyopathy of G&agr;q Transgenic Mice
Background—Although the occurrence of cardiac myocyte apoptosis during heart failure has been documented, its importance in… Expand
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2003
2003
Apoptotic Cell Death and Function of Cryopreserved Porcine Hepatocytes in a Bioartificial Liver
We have previously shown that cryopreservation leads to increased apoptotic death of porcine hepatocytes intended for use in a… Expand
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2001
2001
Inhibition of caspases in vivo protects the rat liver against alcohol-induced sensitization to bacterial lipopolysaccharide.
BACKGROUND The mechanisms of liver sensitization by alcohol to Gram-negative bacterial lipopolysaccharide (LPS) remain elusive… Expand
2001
2001
Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury.
Previous studies have shown that caspase inhibitors are effective at protecting against anti-Fas antibody (alpha-Fas)-mediated… Expand
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Highly Cited
1999
Highly Cited
1999
Apoptosis of sinusoidal endothelial cells occurs during liver preservation injury by a caspase-dependent mechanism.
BACKGROUND Cold ischemia/warm reperfusion (CI/WR) liver injury remains a problem in liver transplants. Sinusoidal endothelial… Expand
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