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National Institutes of Health
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Ligand-induced fit affects binding modes and provokes changes in crystal packing of aldose reductase.
Biochimica et biophysica acta
Corpus ID: 25161867
BACKGROUND Flexibility is a common feature of proteins. For human aldose reductase, a variety of conformers have been observed in…
Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features.
Journal of molecular biology
Corpus ID: 36419083
Inhibition of human aldose reductase (ALR2) evolved as a promising therapeutic concept to prevent late complications of diabetes…
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