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IC 261

Known as: 3-((2,4,6-trimethoxyphenyl)methylidenyl)indolin-2-one, IC-261, IC261 
National Institutes of Health

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3 relations

Broader (2)

IndolesPhloroglucinol
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Cell-based inhibitor screening identifies multiple protein kinases important for circadian clock oscillations
Molecular oscillation of the circadian clock is based on E-box-mediated transcriptional feedback loop formed with clock genes and… 
2013
2013
Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga
BackgroundCasein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally… 
2013
2013
Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga
Casein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally occurring… 
2012
2012
Casein Kinase 1 delta (CK1delta) und Kolorektale Karzinome: Nachweis von Mutationen in der Kinasedomäne von CK1delta sowie Validierung der Effekte von IC261 (3-[(2,4,6-trimethoxyphenyl)-methylidenyl…
2009
2009
Upregulation of casein kinase 1ε in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain
BackgroundNeuropathic pain is a complex chronic pain generated by damage to, or pathological changes in the somatosensory nervous… 
2008
2008
Casein kinase I δ/ɛ phosphorylates topoisomerase IIα at serine-1106 and modulates DNA cleavage activity
We previously reported that phosphorylation of topoisomerase (topo) IIα at serine-1106 (Ser-1106) regulates enzyme activity and… 
2008
2008
Phosphorylation of RhoB by CK1 impedes actin stress fiber organization and epidermal growth factor receptor stabilization.
2007
2007
Intracellular trafficking of a polymorphism in the COOH terminus of the alpha-subunit of the human epithelial sodium channel is modulated by casein kinase 1.
The A663T polymorphism of the alpha-subunit of the human epithelial sodium channel (hENaC) increases the functional and surface… 
2002
2002
Casein kinase I regulates membrane binding by ARF GAP1.
ARF GAP1, a 415-amino acid GTPase activating protein (GAP) for ADP-ribosylation factor (ARF) contains an amino-terminal 115-amino… 
Highly Cited
2000
Highly Cited
2000
IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects
The p53-targeted kinases casein kinase 1δ (CK1δ) and casein kinase 1ε (CK1ε) have been proposed to be involved in regulating DNA… 
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