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Hyperpolarized Carbon C 13 Pyruvate

Known as: Hyperpolarized 13C-Pyruvate, Hyperpolarized Pyruvate (13C) 
A hyperpolarized pyruvate labeled with carbon C 13, with potential usage in the diagnostic imaging of cancer cells. Upon administration, carbon C 13… Expand
National Institutes of Health

Papers overview

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2017
2017
Use of hyperpolarized helium-3 MRI to assess response to ivacaftor treatment in patients with cystic fibrosis.
BACKGROUND This pilot study evaluated the effect of short- and long-term ivacaftor treatment on hyperpolarized 3He-magnetic… Expand
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2017
2017
13 C MR Hyperpolarization of Lactate by Using ParaHydrogen and Metabolic Transformation in Vitro.
Hyperpolarization of the 13 C magnetic resonance signal of l-[1-13 C]lactate has been obtained using the chemically based, cost… Expand
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2014
2014
Assessment of lung function in asthma and COPD using hyperpolarized 129Xe chemical shift saturation recovery spectroscopy and dissolved-phase MRI.
Magnetic-resonance spectroscopy and imaging using hyperpolarized xenon-129 show great potential for evaluation of the most… Expand
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Highly Cited
2013
Highly Cited
2013
Near-unity nuclear polarization with an open-source 129Xe hyperpolarizer for NMR and MRI
Significance Lung diseases comprise the third leading cause of death in the United States and could benefit from new imaging… Expand
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2013
2013
Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors.
Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a… Expand
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2013
2013
Hyperpolarized helium-3 magnetic resonance imaging of chronic obstructive pulmonary disease exacerbation.
A chronic obstructive pulmonary disease (COPD) exsmoker underwent pulmonary function tests and hyperpolarized helium-3 ((3) He… Expand
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Highly Cited
2012
Highly Cited
2012
Evidence for adult lung growth in humans.
A 33-year-old woman underwent a right-sided pneumonectomy in 1995 for treatment of a lung adenocarcinoma. As expected, there was… Expand
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2009
2009
In Vivo Carbon-13 Dynamic MRS and MRSI of Normal and Fasted Rat Liver with Hyperpolarized 13C-Pyruvate
BackgroundThe use of in vivo13C nuclear magnetic resonance spectroscopy in probing metabolic pathways to study normal metabolism… Expand
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2008
2008
Bioenergetic differences selectively sensitize tumorigenic liver progenitor cells to a new gold(I) compound.
A hallmark of cancer cells is their ability to evade apoptosis and mitochondria play a critical role in this process. Delineating… Expand
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Highly Cited
2003
Highly Cited
2003
Role for hydrogen peroxide in flow-induced dilation of human coronary arterioles.
Flow-induced dilation (FID) is dependent largely on hyperpolarization of vascular smooth muscle cells (VSMCs) in human coronary… Expand
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