Hydralazine

Known as: Hydralazinum, Hydrallazin, Phthalazin-1-ylhydrazine 
A phthalazine derivative with antihypertensive effects. Hydralazine exerts its vasodilatory effects through modification of the contractile state of… (More)
National Institutes of Health

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Highly Cited
2003
Highly Cited
2003
Oxidative stress, an imbalance toward the pro-oxidant side of the pro-oxidant/antioxidant homeostasis, occurs in several human… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE The purpose of this study is to evaluate the demethylating and tumor suppressor-reactivating activity of hydralazine and… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE To determine whether hydralazine might decrease DNA methyltransferase (DNMT) expression and induce autoimmunity by… (More)
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Highly Cited
1996
Highly Cited
1996
Hydralazine has been shown to reduce mortality in patients with congestive heart failure when given concomitantly with isosorbide… (More)
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Highly Cited
1996
Highly Cited
1996
Digital-imaging microfluorimetry of the oxidation of hydroethidine (HEt) to ethidium can be used to monitor superoxide (O2… (More)
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Highly Cited
1991
Highly Cited
1991
BACKGROUND To define better the efficacy of vasodilator therapy in the treatment of chronic congestive heart failure, we compared… (More)
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Highly Cited
1989
Highly Cited
1989
Measurement of pH in tissue has shown that the microenvironment in tumors is generally more acidic than in normal tissues. Major… (More)
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Highly Cited
1980
Highly Cited
1980
26 patients with systemic lupus erythematosus (SLE) induced by treatment with the antihypertensive drug hydralazine were… (More)
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Highly Cited
1976
Highly Cited
1976
The hemodynamic effects of oral hydralazine were investigated in ten patients (nine in NYHA Class IV and one in Class III) with… (More)
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