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Hydralazine

Known as: Hydralazinum, Hydrallazin, Phthalazin-1-ylhydrazine 
A phthalazine derivative with antihypertensive effects. Hydralazine exerts its vasodilatory effects through modification of the contractile state of… 
National Institutes of Health

Related topics

Related topics

39 relations
1 ML Hydralazine Hydrochloride 20 MG/ML InjectionArterial Vasodilation [PE]Arteriolar Vasodilation [PE]Congestive heart failure

Broader (5)

Antihypertensive AgentsHydrazineHydrazinesSympatholytics

Narrower (9)

ApresolineBidilHyparezbisvanillyl-hydralazone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery.
A new type of multifunctional polymeric micelle drug carrier for active intracellular drug delivery was prepared and… 
Highly Cited
2004
Highly Cited
2004
Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation.
Iron (Fe) is critical for proliferation, but its precise role in cell cycle progression remains unclear. In this study, we… 
Highly Cited
2002
Highly Cited
2002
Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein.
Highly Cited
1999
Highly Cited
1999
Mitochondria Exert a Negative Feedback on the Propagation of Intracellular Ca2+ Waves in Rat Cortical Astrocytes
We have used digital fluorescence imaging techniques to explore the interplay between mitochondrial Ca2+ uptake and physiological… 
Highly Cited
1997
Highly Cited
1997
Peroxidase substrates stimulate the oxidation of hydralazine to metabolites which cause single-strand breaks in DNA.
Hydrazines are believed to be oxidized by peroxidases to reactive intermediates responsible for a variety of adverse side effects… 
Highly Cited
1989
Highly Cited
1989
Acid pH in tumors and its potential for therapeutic exploitation.
Measurement of pH in tissue has shown that the microenvironment in tumors is generally more acidic than in normal tissues. Major… 
Highly Cited
1988
Highly Cited
1988
Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.
Inhibitors of DNA methylation, such as 5-azacytidine, induce gene expression. We have previously reported that cloned T cells… 
Review
1982
Review
1982
Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.
Highly Cited
1976
Highly Cited
1976
Oral Hydralazine Therapy for Chronic Refractory Heart Failure
SUMMARY The hemodynamic effects of oral hydralazine were investigated in ten patients (nine in NYHA Class IV and one in Class III… 
Review
1973
Review
1973
The epidemiology of systemic lupus erythematosus.
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