Human Immunodeficiency Virus 1 Fusion Inhibitor [EPC]

Several CD4 mimics have been reported as HIV-1 entry inhibitors which can block the interaction between the viral envelope… (More)

HIV-1 membrane fusion plays an important role in the process that HIV-1 entries host cells. As a treatment strategy targeting HIV… (More)

Enfuvirtide (T20), is the first HIV fusion inhibitor approved for treatment of HIV/AIDS patients who fail to respond to the… (More)

To date, several small molecules of CD4 mimics, which can suppress competitively the interaction between an HIV-1 envelope… (More)

Fusion inhibitors are a class of antiretroviral drugs used to prevent entry of HIV into host cells. Many of the fusion inhibitors… (More)

T-20 and T-1249 fusion inhibitor peptides were shown to interact with 1-palmitoyl-2-oleyl-phosphatidylcholine (POPC) (liquid… (More)

T-1249 is a peptide that inhibits the fusion of HIV envelope with the target cell membrane. Recent results indicate that T-1249… (More)