FAQ

HtrA1 protein, human

Known as: IGFBP5-Protease, High-Temperature Requirement A Serine Peptidase 1, HtrA serine peptidase 1, human 
Serine protease HTRA1 (480 aa, ~51 kDa) is encoded by the human HTRA1 gene. This protein plays a role in the proteolysis of IGF-binding proteins.
National Institutes of Health

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Topic mentions per year

1972-2018
02419722018

Related topics

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12 relations
Cell Growth RegulationEnzyme GeneExtracellular ProteinExtracellular Space
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Broader (1)

Serine Endopeptidases

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
HtrA1 protein, human
Hydrolysis
Proteolysis
Serine Endopeptidases
Extracellular Space
Cell Growth Regulation

Papers overview

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2018
2018
The effects of zinc supplementation on primary human retinal pigment epithelium.
Population-based and interventional studies have shown that elevated zinc levels can reduce the progression to advanced age… (More)
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Review
2017
Review
2017
A CARASIL Patient from Americas with Novel Mutation and Atypical Features: Case Presentation and Literature Review.
OBJECTIVE Reporting a novel mutation in the HTRA1 gene in a CARASIL patient from Americas. METHODS Clinical presentation and… (More)
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2016
2016
Novel Function of Serine Protease HTRA1 in Inhibiting Adipogenic Differentiation of Human Mesenchymal Stem Cells via MAP Kinase-Mediated MMP Upregulation.
Adipogenesis is the process by which mesenchymal stem cells (MSCs) develop into lipid-laden adipocytes. Being the dominant cell… (More)
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2013
2013
Serine Protease HTRA1 Antagonizes Transforming Growth Factor-β Signaling by Cleaving Its Receptors and Loss of HTRA1 In Vivo Enhances Bone Formation
HTRA1 is a member of the High Temperature Requirement (HTRA1) family of serine proteases, which play a role in several biological… (More)
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2013
2013
HtrA1 in human urothelial bladder cancer: a secreted protein and a potential novel biomarker.
Our aim was to analyze the expression of the serine protease HtrA1 in human bladder tissue and urine in order to point out its… (More)
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2013
2013
A novel mutation of the high-temperature requirement A serine peptidase 1 (HTRA1) gene in a Chinese family with cerebral autosomal recessive arteriopathy with subcortical infarcts and…
OBJECTIVE Mutations in the high-temperature requirement A serine peptidase 1 (HTRA1) gene were studied in a Chinese family with… (More)
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2013
2013
Downregulation of Serine Protease HTRA1 Is Associated with Poor Survival in Breast Cancer
HTRA1 is a highly conserved serine protease which has been implicated in suppression of epithelial-to-mesenchymal-transition (EMT… (More)
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2006
2006
Coordination chemistry of tetradentate N-donor ligands containing two pyrazolyl-pyridine units separated by a 1,8-naphthyl spacer: dodecanuclear and tetranuclear coordination cages and cyclic…
The tetradentate ligand L(naph) contains two N-donor bidentate pyrazolyl-pyridine units connected to a 1,8-naphthyl core via… (More)
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1984
1984
On the fidelity of DNA replication. The accuracy of T4 DNA polymerases in copying phi X174 DNA in vitro.
The fidelity with which wild type T4 DNA polymerase copies phi X174 amber 3 plus strand DNA at position 587 in vitro has been… (More)
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1972
1972
An analysis of replication errors made by a defective T4 DNA polymerase
An amber mutant in the head protein of bacteriophage T4D, amH36 has been induced to revert by a mutator, tsL56 in gene 43 (the… (More)
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