Homocitrate synthase

Known as: 3-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating) 
 
National Institutes of Health

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Oxo-Acid-Lyases

Papers overview

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2016
2016
Characterization of recombinant homocitrate synthase from Candida albicans.
LYS21 and LYS22 genes from Candida albicans encoding isoforms of homocitrate synthase (HCS), an enzyme catalyzing the first… (More)
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2011
2011
The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in Saccharomyces cerevisiae.
In Saccharomyces cerevisiae, the first committed step in the lysine (Lys) biosynthetic pathway is catalysed by the Lys20 and… (More)
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2010
2010
Evaluation of lysine biosynthesis as an antifungal drug target: biochemical characterization of Aspergillus fumigatus homocitrate synthase and virulence studies.
Aspergillus fumigatus is the main cause of severe invasive aspergillosis. To combat this life-threatening infection, only limited… (More)
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2010
2010
Structural basis for L-lysine feedback inhibition of homocitrate synthase.
The alpha-aminoadipate pathway of lysine biosynthesis is modulated at the transcriptional and biochemical levels by feedback… (More)
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2010
2010
Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage.
The enzyme homocitrate synthase (HCS) catalyzes the first step in lysine biosynthesis, and early biochemical data placed it in… (More)
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2010
2010
Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from Thermus thermophilus.
Homocitrate synthase (HCS) catalyzes aldol-type condensation of acetyl coenzyme A (acetyl-CoA) and alpha-ketoglutarate (alpha-KG… (More)
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2006
2006
Inactivation of homocitrate synthase causes lysine auxotrophy in copper/zinc-containing superoxide dismutase-deficient yeast Schizosaccharomyces pombe.
The fission yeast Schizosaccharomyces pombe lacking copper/zinc-containing superoxide dismutase (CuZn-SOD) is auxotrophic for… (More)
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2005
2005
Regulatory mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. I. Kinetic studies.
Homocitrate synthase (HCS) catalyzes one of the regulated steps of the alpha-aminoadipate pathway for lysine biosynthesis in… (More)
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2004
2004
Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae.
Kinetic data have been collected suggesting a preferred sequential ordered kinetic mechanism for the histidine-tagged homocitrate… (More)
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2002
2002
Characterization of bacterial homocitrate synthase involved in lysine biosynthesis.
In Thermus thermophilus homocitrate synthase (HCS) catalyzes the initial reaction of lysine biosynthesis through alpha… (More)
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