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Homocitrate synthase

Known as: 3-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating) 
National Institutes of Health

Related topics

Related topics

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Broader (1)

Oxo-Acid-Lyases

Papers overview

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2019
2019
Spectroscopic Characterization of an Eight-Iron Nitrogenase Cofactor Precursor That Lacks the "9th Sulfur".
Nitrogenase catalyzes the reduction of N2 to NH₄+ at its cofactor site. Designated the M-cluster, this [MoFe₇S₉C(R-homocitrate… 
2017
2017
De Novo Biosynthesis of Glutarate via α-Keto Acid Carbon Chain Extension and Decarboxylation Pathway in Escherichia coli.
Microbial based bioplastics are promising alternatives to petroleum based synthetic plastics due to their renewability and… 
Highly Cited
2010
Highly Cited
2010
Evaluation of Lysine Biosynthesis as an Antifungal Drug Target: Biochemical Characterization of Aspergillus fumigatus Homocitrate Synthase and Virulence Studies
ABSTRACT Aspergillus fumigatus is the main cause of severe invasive aspergillosis. To combat this life-threatening infection… 
2010
2010
Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage.
The enzyme homocitrate synthase (HCS) catalyzes the first step in lysine biosynthesis, and early biochemical data placed it in… 
2010
2010
Structural Basis for l-Lysine Feedback Inhibition of Homocitrate Synthase*♦
The α-aminoadipate pathway of lysine biosynthesis is modulated at the transcriptional and biochemical levels by feedback… 
2009
2009
Mechanism of Substrate Recognition and Insight into Feedback Inhibition of Homocitrate Synthase from Thermus thermophilus*
Homocitrate synthase (HCS) catalyzes aldol-type condensation of acetyl coenzyme A (acetyl-CoA) and α-ketoglutarate (α-KG) to… 
Highly Cited
2009
Highly Cited
2009
Host plant genome overcomes the lack of a bacterial gene for symbiotic nitrogen fixation
Homocitrate is a component of the iron–molybdenum cofactor in nitrogenase, where nitrogen fixation occurs. NifV, which encodes… 
2006
2006
Evidence for a dynamic role for homocitrate during nitrogen fixation: the effect of substitution at the alpha-Lys426 position in MoFe-protein of Azotobacter vinelandii.
Although it is generally accepted that the active site of nitrogenase is located on the FeMo-cofactor, the exact site(s) of N2… 
2005
2005
Regulatory Mechanism of Histidine-tagged Homocitrate Synthase from Saccharomyces cerevisiae
Homocitrate synthase (HCS) catalyzes one of the regulated steps of the α-aminoadipate pathway for lysine biosynthesis in fungi… 
2004
2004
Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae.
Kinetic data have been collected suggesting a preferred sequential ordered kinetic mechanism for the histidine-tagged homocitrate… 
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