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Homocitrate synthase
Known as:
3-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Oxo-Acid-Lyases
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Spectroscopic Characterization of an Eight-Iron Nitrogenase Cofactor Precursor That Lacks the "9th Sulfur".
A. Jasniewski
,
Jarett Wilcoxen
,
+5 authors
M. Ribbe
Angewandte Chemie
2019
Corpus ID: 199573405
Nitrogenase catalyzes the reduction of N2 to NH₄+ at its cofactor site. Designated the M-cluster, this [MoFe₇S₉C(R-homocitrate…
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2017
2017
De Novo Biosynthesis of Glutarate via α-Keto Acid Carbon Chain Extension and Decarboxylation Pathway in Escherichia coli.
Jian Wang
,
Yifei Wu
,
Xinxiao Sun
,
Qipeng Yuan
,
Yajun Yan
ACS Synthetic Biology
2017
Corpus ID: 3842923
Microbial based bioplastics are promising alternatives to petroleum based synthetic plastics due to their renewability and…
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Highly Cited
2010
Highly Cited
2010
Evaluation of Lysine Biosynthesis as an Antifungal Drug Target: Biochemical Characterization of Aspergillus fumigatus Homocitrate Synthase and Virulence Studies
F. Schöbel
,
I. Jacobsen
,
M. Brock
Eukaryotic Cell
2010
Corpus ID: 206744007
ABSTRACT Aspergillus fumigatus is the main cause of severe invasive aspergillosis. To combat this life-threatening infection…
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2010
2010
Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage.
E. Scott
,
L. Pillus
Genes & Development
2010
Corpus ID: 5164189
The enzyme homocitrate synthase (HCS) catalyzes the first step in lysine biosynthesis, and early biochemical data placed it in…
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2010
2010
Structural Basis for l-Lysine Feedback Inhibition of Homocitrate Synthase*♦
Stacie L. Bulfer
,
E. Scott
,
L. Pillus
,
R. Trievel
Journal of Biological Chemistry
2010
Corpus ID: 34713592
The α-aminoadipate pathway of lysine biosynthesis is modulated at the transcriptional and biochemical levels by feedback…
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2009
2009
Mechanism of Substrate Recognition and Insight into Feedback Inhibition of Homocitrate Synthase from Thermus thermophilus*
T. Okada
,
T. Tomita
,
A. P. Wulandari
,
T. Kuzuyama
,
M. Nishiyama
Journal of Biological Chemistry
2009
Corpus ID: 12432018
Homocitrate synthase (HCS) catalyzes aldol-type condensation of acetyl coenzyme A (acetyl-CoA) and α-ketoglutarate (α-KG) to…
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Highly Cited
2009
Highly Cited
2009
Host plant genome overcomes the lack of a bacterial gene for symbiotic nitrogen fixation
T. Hakoyama
,
K. Niimi
,
+16 authors
N. Suganuma
Nature
2009
Corpus ID: 4349616
Homocitrate is a component of the iron–molybdenum cofactor in nitrogenase, where nitrogen fixation occurs. NifV, which encodes…
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2006
2006
Evidence for a dynamic role for homocitrate during nitrogen fixation: the effect of substitution at the alpha-Lys426 position in MoFe-protein of Azotobacter vinelandii.
M. Durrant
,
Amanda Francis
,
D. Lowe
,
W. Newton
,
K. Fisher
Biochemical Journal
2006
Corpus ID: 1744215
Although it is generally accepted that the active site of nitrogenase is located on the FeMo-cofactor, the exact site(s) of N2…
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2005
2005
Regulatory Mechanism of Histidine-tagged Homocitrate Synthase from Saccharomyces cerevisiae
B. Andi
,
A. West
,
P. Cook
Journal of Biological Chemistry
2005
Corpus ID: 26291342
Homocitrate synthase (HCS) catalyzes one of the regulated steps of the α-aminoadipate pathway for lysine biosynthesis in fungi…
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2004
2004
Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae.
B. Andi
,
A. West
,
P. Cook
Biochemistry
2004
Corpus ID: 9574134
Kinetic data have been collected suggesting a preferred sequential ordered kinetic mechanism for the histidine-tagged homocitrate…
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