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Higher Order Chromatin Structure

Known as: Higher Order Chromatin Folding, Higher Order Structure 
Refers to various levels of DNA packaging in the chromosomes above that of the nucleosome. Includes the chromatin fiber and higher levels of folding… Expand
National Institutes of Health

Papers overview

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2019
2019
Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics
The increased interest in using monoclonal antibodies (mAbs) as a platform for biopharmaceuticals has led to the need for new… Expand
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2017
2017
Multivariate Analysis of Two-Dimensional 1H, 13C Methyl NMR Spectra of Monoclonal Antibody Therapeutics To Facilitate Assessment of Higher Order Structure.
Two-dimensional (2D) 1H-13C methyl NMR provides a powerful tool to probe the higher order structure (HOS) of monoclonal… Expand
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2017
2017
Application of 2D‐NMR with room temperature NMR probes for the assessment of the higher order structure of filgrastim
&NA; The higher order structure (HOS) of biotherapeutics is a critical quality attribute that can be evaluated by nuclear… Expand
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2017
2017
Assessment of the structure of pegylated‐recombinant protein therapeutics by the NMR fingerprint assay
&NA; A number of recombinant protein therapeutic products, such as filgrastim (methionyl granulocyte colony stimulating factor… Expand
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2016
2016
Evaluation of Ion Mobility-Mass Spectrometry for Comparative Analysis of Monoclonal Antibodies
AbstractAnalytical techniques capable of detecting changes in structure are necessary to monitor the quality of monoclonal… Expand
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2015
2015
2D 1HN, 15N Correlated NMR Methods at Natural Abundance for Obtaining Structural Maps and Statistical Comparability of Monoclonal Antibodies
PurposeHigh-resolution nuclear magnetic resonance spectroscopy (NMR) provides a robust approach for producing unique spectral… Expand
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2015
2015
On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods.
An important aspect in the analytical characterization of protein therapeutics is the comprehensive characterization of higher… Expand
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2014
2014
Use of the amide II infrared band of proteins for secondary structure determination and comparability of higher order structure.
Demonstrating comparability of secondary structure composition as part of higher order structure (HOS) in therapeutic proteins is… Expand
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2013
2013
Assessment of higher order structure comparability in therapeutic proteins using nuclear magnetic resonance spectroscopy.
In this work, we applied nuclear magnetic resonance (NMR) spectroscopy to rapidly assess higher order structure (HOS… Expand
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1992
1992
Nucleic acid targeted drug design
"Designing Drugs that Interact with Nucleic Acids, Thomas J. Perun and C. L. Propst Methods Structural Studies of Drug-DNA… Expand
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