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Higher Order Chromatin Structure

Known as: Higher Order Chromatin Folding, Higher Order Structure 
Refers to various levels of DNA packaging in the chromosomes above that of the nucleosome. Includes the chromatin fiber and higher levels of folding… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2017
0246820002017

Papers overview

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2017
2017
Effect of Polysorbate 20 and Polysorbate 80 on the Higher-Order Structure of a Monoclonal Antibody and Its Fab and Fc Fragments Probed Using 2D Nuclear Magnetic Resonance Spectroscopy.
We examined how polysorbate 20 (PS20; Tween 20) and polysorbate 80 (PS80; Tween 80) affect the higher-order structure of a… (More)
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2016
2016
Covalent Labeling Denaturation Mass Spectrometry for Sensitive Localized Higher Order Structure Comparisons.
Protein higher order structure (HOS) describes the three-dimensional folding arrangement of a given protein and plays critical… (More)
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2015
2015
2D 1HN, 15N Correlated NMR Methods at Natural Abundance for Obtaining Structural Maps and Statistical Comparability of Monoclonal Antibodies
High-resolution nuclear magnetic resonance spectroscopy (NMR) provides a robust approach for producing unique spectral signatures… (More)
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2015
2015
Technical decision-making with higher order structure data: starting a new dialogue.
Characterization of the higher order structure (HOS) of biological products has been growing in importance in recent years… (More)
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2015
2015
Technical decision making with higher order structure data: impact of a formulation change on the higher order structure and stability of a mAb.
Changes in formulation may be required during the development of protein therapeutics. Some of the changes may alter the protein… (More)
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2015
2015
Technical decision making with higher order structure data: higher order structure characterization during protein therapeutic candidate screening.
Protein therapeutics differ considerably from small molecule drugs because of the presence of higher order structure (HOS), post… (More)
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2013
2013
Divergence of Mammalian Higher Order Chromatin Structure Is Associated with Developmental Loci
Several recent studies have examined different aspects of mammalian higher order chromatin structure - replication timing, lamina… (More)
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2013
2013
Assessment of Physical Stability of an Antibody Drug Conjugate by Higher Order Structure Analysis: Impact of Thiol- Maleimide Chemistry
To provide a systematic biophysical approach towards a better understanding of impact of conjugation chemistry on higher order… (More)
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2013
2013
Development of antibody arrays for monoclonal antibody Higher Order Structure analysis
Antibody arrays were developed to probe a monoclonal antibody's three-dimensional structure (3-D structure). Peptides with… (More)
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2008
2008
Interactions of Histones with DNA: Nucleosome Assembly, Stability, Dynamics, and Higher Order Structure
The genome of a human cell comprises 6 10 DNA base pairs corresponding to a DNA chain with a total contour length of about 2m… (More)
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