Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Higher Order Chromatin Structure

Known as: Higher Order Chromatin Folding, Higher Order Structure 
Refers to various levels of DNA packaging in the chromosomes above that of the nucleosome. Includes the chromatin fiber and higher levels of folding… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The increased interest in using monoclonal antibodies (mAbs) as a platform for biopharmaceuticals has led to the need for new… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2017
2017
Two-dimensional (2D) 1H-13C methyl NMR provides a powerful tool to probe the higher order structure (HOS) of monoclonal… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2017
2017
&NA; The higher order structure (HOS) of biotherapeutics is a critical quality attribute that can be evaluated by nuclear… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
2017
2017
&NA; A number of recombinant protein therapeutic products, such as filgrastim (methionyl granulocyte colony stimulating factor… Expand
Is this relevant?
2016
2016
AbstractAnalytical techniques capable of detecting changes in structure are necessary to monitor the quality of monoclonal… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2015
2015
PurposeHigh-resolution nuclear magnetic resonance spectroscopy (NMR) provides a robust approach for producing unique spectral… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2015
2015
An important aspect in the analytical characterization of protein therapeutics is the comprehensive characterization of higher… Expand
Is this relevant?
2014
2014
Demonstrating comparability of secondary structure composition as part of higher order structure (HOS) in therapeutic proteins is… Expand
Is this relevant?
2013
2013
In this work, we applied nuclear magnetic resonance (NMR) spectroscopy to rapidly assess higher order structure (HOS… Expand
Is this relevant?
1992
1992
"Designing Drugs that Interact with Nucleic Acids, Thomas J. Perun and C. L. Propst Methods Structural Studies of Drug-DNA… Expand
Is this relevant?