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Higher Order Chromatin Structure

Known as: Higher Order Chromatin Folding, Higher Order Structure 
Refers to various levels of DNA packaging in the chromosomes above that of the nucleosome. Includes the chromatin fiber and higher levels of folding… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Current Trends in Biotherapeutic Higher Order Structure Characterization by Irreversible Covalent Footprinting Mass Spectrometry.
BACKGROUND Biotherapeutics, particularly monoclonal antibodies (mAbs), are a maturing class of drugs capable of treating a wide… 
2019
2019
Quadrupole Dalton-Based Controlled Proteolysis Method for Characterization of Higher Order Protein Structure.
The higher order structure (HOS) of proteins plays a critical role in the efficacy and stability of biological drugs… 
2017
2017
Assessment of the structure of pegylated‐recombinant protein therapeutics by the NMR fingerprint assay
2017
2017
Chemometric Methods to Quantify 1D and 2D NMR Spectral Differences Among Similar Protein Therapeutics
NMR spectroscopy is an emerging analytical tool for measuring complex drug product qualities, e.g., protein higher order… 
2017
2017
Characterization of biopharmaceutical stability with Differential Scanning Calorimetry : Candidate selection for developability
  • 2017
  • Corpus ID: 117959381
The stability of a biopharmaceutical protein is critical to the success or failure of the development of a viable drug. Protein… 
2016
2016
Covalent Labeling Denaturation Mass Spectrometry for Sensitive Localized Higher Order Structure Comparisons.
Protein higher order structure (HOS) describes the three-dimensional folding arrangement of a given protein and plays critical… 
2015
2015
2D 1HN, 15N Correlated NMR Methods at Natural Abundance for Obtaining Structural Maps and Statistical Comparability of Monoclonal Antibodies
High-resolution nuclear magnetic resonance spectroscopy (NMR) provides a robust approach for producing unique spectral signatures… 
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