Skip to search formSkip to main contentSkip to account menu
You are currently offline. Some features of the site may not work correctly.

Hexosaminidase A

Known as: Hex A, Beta-N-acetylhexosaminidase.A, beta N Acetylhexosaminidase A 
A mammalian beta-hexosaminidase isoform that is a heteromeric protein comprized of both hexosaminidase alpha and hexosaminidase beta subunits… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Hexosaminidase A deficiency results in a group of neurodegenerative disorders caused by intralysosomal storage of the specific… Expand
  • table 2
  • table 3
Highly Cited
2006
Highly Cited
2006
Lysosomal beta-hexosaminidase A (Hex A) is essential for the degradation of GM2 gangliosides in the central and peripheral… Expand
Highly Cited
2003
Highly Cited
2003
In humans, two major beta-hexosaminidase isoenzymes exist: Hex A and Hex B. Hex A is a heterodimer of subunits alpha and beta (60… Expand
1993
1993
Deficient activity of beta-hexosaminidase A (Hex A), resulting from mutations in the HEXA gene, typically causes Tay-Sachs… Expand
Highly Cited
1992
Highly Cited
1992
Deficiency of beta-hexosaminidase A (Hex A) activity typically results in Tay-Sachs disease. However, healthy subjects found to… Expand
Highly Cited
1991
Highly Cited
1991
Ganglioside GD1a-GalNAc was isolated from Tay-Sachs brain, tritium-labeled in its sphingosine moiety, and its enzymic degradation… Expand
Highly Cited
1986
Highly Cited
1986
Deficiency of hexosaminidase A (Hex A) in adults was found in 15 individuals from nine unrelated Ashkenazi families; 14… Expand
Highly Cited
1978
Highly Cited
1978
Human kidney extracts heated to 60 degrees and devoid of hexosaminidase activity (2-acetamido-2-deoxy-beta-D-glucoside… Expand
Highly Cited
1976
Highly Cited
1976
To determine whether ligand-receptor interactions could engender the selective uptake by deficient cells of enzyme-laden… Expand
Highly Cited
1975
Highly Cited
1975
Two major and several minor isozymes of hexosaminidase (Hex) exist in human tissues. In Tay-Sachs disease Hex A is missing but… Expand