Hexosaminidase A

Known as: Hex A, Beta-N-acetylhexosaminidase.A, beta N Acetylhexosaminidase A 
A mammalian beta-hexosaminidase isoform that is a heteromeric protein comprized of both hexosaminidase alpha and hexosaminidase beta subunits… (More)
National Institutes of Health

Papers overview

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2013
2013
BACKGROUND A sensitive alcohol marker, β-hexosaminidase (HEX), in the saliva of alcoholics, is investigated for the first time… (More)
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2011
2011
Late-onset GM2 gangliosidosis is an autosomal recessive, neurodegenerative, lysosomal storage disease, caused by deficiency of… (More)
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2006
2006
Lysosomal beta-hexosaminidase A (Hex A) is essential for the degradation of GM2 gangliosides in the central and peripheral… (More)
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2005
2005
Therapy for neurodegenerative lysosomal Tay-Sachs (TS) disease requires active hexosaminidase (Hex) A production in the central… (More)
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Highly Cited
2003
Highly Cited
2003
In humans, two major beta-hexosaminidase isoenzymes exist: Hex A and Hex B. Hex A is a heterodimer of subunits alpha and beta (60… (More)
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2002
2002
Human lysosomal beta-hexosaminidases remove terminal beta-glycosidically bound N-acetylhexosamine residues from a number of… (More)
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1991
1991
Ganglioside GD1a-GalNAc was isolated from Tay-Sachs brain, tritium-labeled in its sphingosine moiety, and its enzymic degradation… (More)
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1986
1986
Deficiency of hexosaminidase A (Hex A) in adults was found in 15 individuals from nine unrelated Ashkenazi families; 14… (More)
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1978
1978
Human kidney extracts heated to 60 degrees and devoid of hexosaminidase activity (2-acetamido-2-deoxy-beta-D-glucoside… (More)
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1975
1975
Two major and several minor isozymes of hexosaminidase (Hex) exist in human tissues. In Tay-Sachs disease Hex A is missing but… (More)
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