Hereditary Malignant Neoplasm

Known as: Familial Cancer, Familial Malignant Neoplasm, Hereditary Cancer 
Cancer that occurs in families more often than would be expected by chance. These cancers often occur at an early age, and may indicate the presence… (More)
National Institutes of Health

Papers overview

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Review
2007
Review
2007
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/phosphatidylinositol 3-kinase (PI3K)/AKT constitute an important… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE To compare the effectiveness of mammography, breast ultrasound, and magnetic resonance imaging (MRI) for surveillance of… (More)
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Review
2005
Review
2005
Every year, more than 945000 people develop colorectal cancer worldwide, and around 492000 patients die. This form of cancer… (More)
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Highly Cited
2000
Highly Cited
2000
von Hippel–Lindau (VHL) disease is a hereditary cancer syndrome that is characterized by the development of multiple vascular… (More)
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Highly Cited
2000
Highly Cited
2000
The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in cellular responses to oxygen availability… (More)
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Highly Cited
2000
Highly Cited
2000
CONTEXT Most hereditary ovarian cancers are associated with germline mutations in BRCA1 or BRCA2. Attempts to define the clinical… (More)
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Highly Cited
1999
Highly Cited
1999
The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer predisposition syndromes. PTEN is a… (More)
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Review
1996
Review
1996
According to a “two-hit” model, dominantly inherited predisposition to cancer entails a germline mutation, while tumorigenesis… (More)
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Highly Cited
1996
Highly Cited
1996
OBJECTIVES To identify predictors of utilization of breast-ovarian cancer susceptibility (BRCA1 gene) testing and to evaluate… (More)
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Highly Cited
1993
Highly Cited
1993
Recent reports have suggested that one or more genes may cause replication errors (RER) during colorectal tumorigenesis… (More)
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