Hereditary Malignant Neoplasm

Known as: Familial Cancer, Familial Malignant Neoplasm, Hereditary Cancer 
Cancer that occurs in families more often than would be expected by chance. These cancers often occur at an early age, and may indicate the presence… (More)
National Institutes of Health

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Papers overview

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Review
2007
Review
2007
PTEN, more than the AKT pathway.
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/phosphatidylinositol 3-kinase (PI3K)/AKT constitute an important… (More)
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Highly Cited
2005
Highly Cited
2005
Mammography, breast ultrasound, and magnetic resonance imaging for surveillance of women at high familial risk for breast cancer.
PURPOSE To compare the effectiveness of mammography, breast ultrasound, and magnetic resonance imaging (MRI) for surveillance of… (More)
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Review
2005
Review
2005
Colorectal cancer
Every year, more than 945000 people develop colorectal cancer worldwide, and around 492000 patients die. This form of cancer… (More)
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Highly Cited
2000
Highly Cited
2000
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein
von Hippel–Lindau (VHL) disease is a hereditary cancer syndrome that is characterized by the development of multiple vascular… (More)
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Highly Cited
2000
Highly Cited
2000
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in cellular responses to oxygen availability… (More)
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Highly Cited
2000
Highly Cited
2000
Clinicopathologic features of BRCA-linked and sporadic ovarian cancer.
CONTEXT Most hereditary ovarian cancers are associated with germline mutations in BRCA1 or BRCA2. Attempts to define the clinical… (More)
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Highly Cited
1999
Highly Cited
1999
Crystal Structure of the PTEN Tumor Suppressor Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association
The PTEN tumor suppressor is mutated in diverse human cancers and in hereditary cancer predisposition syndromes. PTEN is a… (More)
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Review
1996
Review
1996
Hereditary cancer: Two hits revisited
According to a “two-hit” model, dominantly inherited predisposition to cancer entails a germline mutation, while tumorigenesis… (More)
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Highly Cited
1996
Highly Cited
1996
BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes.
OBJECTIVES To identify predictors of utilization of breast-ovarian cancer susceptibility (BRCA1 gene) testing and to evaluate… (More)
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Highly Cited
1993
Highly Cited
1993
Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.
Recent reports have suggested that one or more genes may cause replication errors (RER) during colorectal tumorigenesis… (More)
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