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Dabigatran is an oral direct thrombin inhibitor that has been shown to be an effective alternative to warfarin in… Expand The introduction of valve replacement surgery in the early 1960s has dramatically improved the outcome of patients with valvular… Expand Context Thirteen new randomized, controlled trials are available since a 1999 meta-analysis of antithrombotic agents for stroke… Expand During the past decade, single gene disruption in mice and large-scale mutagenesis screens in zebrafish have elucidated many… Expand BackgroundFor nearly a century, the mechanical failure of calcified heart valves was attributed to a passive degenerative process… Expand Background—Previous tissue engineering approaches to create heart valves have been limited by the structural immaturity and… Expand BACKGROUND
The management of women with prosthetic heart valves during pregnancy poses a particular challenge as there are no… Expand BACKGROUND
The optimal intensity of oral anticoagulant therapy for patients with mechanical heart valves (i.e., the level at… Expand BackgroundPatients with mechanical heart valve prostheses may experience valve thrombosis and subsequent systemic embolism for… Expand Abstract 1.1. Standard hydrokinetic orifice formulas have been applied to stenotic mitral, pulmonic, tricuspid, and aortic valves… Expand