FAQ

HSF2 gene

Known as: heat shock transcription factor 2, HEAT-SHOCK TRANSCRIPTION FACTOR 2, HEAT-SHOCK FACTOR 2 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
0246819912017

Papers overview

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2007
2007
HSF2 binds to the Hsp90, Hsp27, and c-Fos promoters constitutively and modulates their expression.
Although the vast majority of genomic DNA is tightly compacted during mitosis, the promoter regions of a number of genes remain… (More)
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2006
2006
Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes.
Clusterin is a secreted protein chaperone up-regulated in several pathologies, including cancer and neurodegenerative diseases… (More)
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2004
2004
Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility.
Heat shock factors (Hsfs) are major transactivators of heat shock proteins but are also involved in regulation of other genes… (More)
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2003
2003
Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70.
The heat-shock response is characterized by the activation of heat-shock transcription factor 1 (HSF1), followed by increased… (More)
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Highly Cited
1998
Highly Cited
1998
Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway.
Mammalian cells coexpress a family of heat shock factors (HSFs) whose activities are regulated by diverse stress conditions to… (More)
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Highly Cited
1994
Highly Cited
1994
Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription.
Two members of the heat shock transcription factor (HSF) family, HSF1 and HSF2, both function as transcriptional activators of… (More)
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Highly Cited
1993
Highly Cited
1993
Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.
The existence of multiple heat shock factor (HSF) genes in higher eukaryotes has promoted questions regarding the functions of… (More)
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Highly Cited
1993
Highly Cited
1993
Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1.
Transcriptional activity of heat shock (hsp) genes is controlled by a heat-activated, group-specific transcription factor(s… (More)
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1993
1993
Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2.
HSF2, one of the heat shock transcription factors in mammalian cells, is localized to the cytoplasm during normal growth and… (More)
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Highly Cited
1991
Highly Cited
1991
Molecular cloning and expression of a human heat shock factor, HSF1.
Human cells respond to heat stress by inducing the binding of a preexisting transcriptional activator (heat shock factor, HSF) to… (More)
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