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HSF1 gene

Known as: HEAT-SHOCK TRANSCRIPTION FACTOR 1, HEAT-SHOCK FACTOR 1, heat shock transcription factor 1 
This gene plays a role in the activation of transcription in response to environmental stress.
National Institutes of Health

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HSF1 wt Allele
HSFY1 geneHSFY2 geneHeat Shock Factor Protein 1Homo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Rethinking HSF1 in Stress, Development, and Organismal Health.
Review
2016
Review
2016
HSF1: Guardian of Proteostasis in Cancer.
Highly Cited
2015
Highly Cited
2015
Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.
Highly Cited
2013
Highly Cited
2013
Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State
Introduction Ribosome biogenesis is commonly up-regulated to satisfy the increased anabolic demands associated with malignant… 
Highly Cited
2010
Highly Cited
2010
Comparative transcriptome profiling analyses during the lag phase uncover YAP1, PDR1, PDR3, RPN4, and HSF1 as key regulatory genes in genomic adaptation to the lignocellulose derived inhibitor HMF…
BackgroundThe yeast Saccharomyces cerevisiae is able to adapt and in situ detoxify lignocellulose derived inhibitors such as… 
Review
2007
Review
2007
Chaperone regulation of the heat shock protein response.
The heat shock protein response appears to be triggered primarily by nonnative proteins accumulating in a stressed cell and… 
Highly Cited
2002
Highly Cited
2002
Interspecific- and acclimation-induced variation in levels of heat-shock proteins 70 (hsp70) and 90 (hsp90) and heat-shock transcription factor-1 (HSF1) in congeneric marine snails (genus Tegula…
In our previous studies of heat-shock protein (hsp) expression in congeneric marine gastropods of the genus Tegula, we observed… 
Review
2000
Review
2000
NO Synthase and NO-Dependent Signal Pathways in Brain Aging and Neurodegenerative Disorders: The Role of Oxidant/Antioxidant Balance
Nitric oxide and other reactive nitrogen species appear to play several crucial roles in the brain. These include physiological… 
Highly Cited
2000
Highly Cited
2000
The Skn7 response regulator of Saccharomyces cerevisiae interacts with Hsf1 in vivo and is required for the induction of heat shock genes by oxidative stress.
The Skn7 response regulator has previously been shown to play a role in the induction of stress-responsive genes in yeast, e.g… 
Highly Cited
1995
Highly Cited
1995
Quercetin suppresses heat shock response by down regulation of HSF1.
A bioflavonoid quercetin suppressed the stress response in heat-shocked cells and we have investigated the inhibitory mechanism… 
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