FAQ

HSF1 gene

Known as: HEAT-SHOCK TRANSCRIPTION FACTOR 1, HEAT-SHOCK FACTOR 1, heat shock transcription factor 1 
This gene plays a role in the activation of transcription in response to environmental stress.

Topic mentions per year

Topic mentions per year

1991-2017
05019912017

Related topics

Related topics

6 relations
HSFY1 geneHSFY2 geneHeat Shock Factor Protein 1Homo sapiens
(More)

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
HSF1 gene
dna binding
Homo sapiens
Transcriptional Regulation
Heat Shock Factor Protein 1
HSFY1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers
Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell… (More)
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Highly Cited
2007
Highly Cited
2007
Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of Carcinogenesis
Heat shock factor 1 (HSF1) is the master regulator of the heat shock response in eukaryotes, a very highly conserved protective… (More)
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Highly Cited
2005
Highly Cited
2005
Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models.
Polyglutamine diseases are inherited neurodegenerative diseases characterized by misfolding and aggregation of proteins… (More)
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Highly Cited
2003
Highly Cited
2003
CHIP activates HSF1 and confers protection against apoptosis and cellular stress.
Induction of molecular chaperones is the characteristic protective response to environmental stress, and is regulated by a… (More)
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Highly Cited
2003
Highly Cited
2003
Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress.
The activation of eukaryotic heat shock protein (Hsp) gene expression occurs in response to a wide variety of cellular stresses… (More)
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Highly Cited
1999
Highly Cited
1999
HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice.
HSF1 is the major heat shock transcriptional factor that binds heat shock element (HSE) in the promoter of heat shock proteins… (More)
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Highly Cited
1998
Highly Cited
1998
Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1
Heat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trigger activation of heat shock protein… (More)
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Highly Cited
1998
Highly Cited
1998
Molecular chaperones as HSF1-specific transcriptional repressors.
The rapid yet transient transcriptional activation of heat shock genes is mediated by the reversible conversion of HSF1 from an… (More)
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Highly Cited
1993
Highly Cited
1993
Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1.
Transcriptional activity of heat shock (hsp) genes is controlled by a heat-activated, group-specific transcription factor(s… (More)
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Highly Cited
1991
Highly Cited
1991
Molecular cloning and expression of a human heat shock factor, HSF1.
Human cells respond to heat stress by inducing the binding of a preexisting transcriptional activator (heat shock factor, HSF) to… (More)
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