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HSF1 gene

Known as: HEAT-SHOCK TRANSCRIPTION FACTOR 1, HEAT-SHOCK FACTOR 1, heat shock transcription factor 1 
This gene plays a role in the activation of transcription in response to environmental stress.
National Institutes of Health

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HSF1 wt Allele
HSFY1 geneHSFY2 geneHeat Shock Factor Protein 1Homo sapiens

Papers overview

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Highly Cited
2014
Highly Cited
2014
The Systemic Amyloid Precursor Transthyretin (TTR) Behaves as a Neuronal Stress Protein Regulated by HSF1 in SH-SY5Y Human Neuroblastoma Cells and APP23 Alzheimer's Disease Model Mice
Increased neuronal synthesis of transthyretin (TTR) may favorably impact on Alzheimer's disease (AD) because TTR has been shown… 
Highly Cited
2010
Highly Cited
2010
Regulation of the heat shock response under anoxia in the turtle, Trachemys scripta elegans
The effects of 20 h of anoxic submergence in cold water and 5 h of aerobic recovery on the heat shock response were analyzed in… 
Highly Cited
2006
Highly Cited
2006
The Natural Osmolyte Trehalose Is a Positive Regulator of the Heat-Induced Activity of Yeast Heat Shock Transcription Factor
ABSTRACT In Saccharomyces cerevisiae, the intracellular concentration of trehalose increases rapidly in response to many… 
2004
2004
Regulation of myocardial heat shock protein 70 gene expression following exercise.
Highly Cited
2004
Highly Cited
2004
HSF1 Modulation of Hsp70 mRNA Polyadenylation via Interaction with Symplekin*
Induction of heat shock protein (HSP) gene expression by stress is initiated by binding of HSF1 to HSP gene promoters to increase… 
2004
2004
Characterization of the hsp70 response in lymphoblasts from aged and centenarian subjects and differential effects of in vitro zinc supplementation
2003
2003
Insights into the regulation of heat shock transcription factor 1 SUMO-1 modification.
2001
2001
HSF1/hsp72 pathway as an endogenous anti‐inflammatory system
2001
2001
Activation of the heat shock response: relationship to energy metabolites. A (31)P NMR study in rat hearts.
Heat shock factor (HSF), the transcription factor for the heat shock proteins, is activated by cardiac ischemia, but the… 
2001
2001
Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response.
OBJECTIVE During joint loading, chondrocytes in the articular cartilage are subjected to gradients of high compressive… 
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