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HP 749 (besipirdine; Hoechst-Roussel Pharmaceuticals, Inc., Somerville, NJ) and related analogs belonging to the N-(4-pyridinyl… Expand Besipirdine displays potent adrenergic activity in a variety of pharmacological and behavioral tests. Based on this property, we… Expand The aim of the present paper is to report on the adrenergic and serotonergic effects of besipirdine (HP 749) in vivo and to… Expand We have described the interaction of besipirdine (HP 749, N-(n-propyl)-N-(4-pyridinyl)-1H-indol-1-amine hydrochloride) with… Expand Summary:Besipirdine hydrochloride (HP 749) is an indole-substituted analog of 4- aminopyridine. Besipirdine enhances both… Expand Besipirdine hydrochloride (HP 749) is an indole‐substituted analog of 4‐aminopyridine. Besipirdine enhances both cholinergic and… Expand Besipirdine hydrochloride (HP 749) is an indole-substituted analog of 4-aminopyridine. Besipirdine enhances both cholinergic and… Expand HP 749 was absorbed slowly in the conscious monkey after single oral doses (10, 20, and 40 mg/kg), with gradual metabolism to the… Expand 1 Besipirdine (HP 749) is a compound undergoing clinical trials for efficacy in treating Alzheimer's disease. Among other… Expand N-(n-Propyl)-N-(4-pyridinyl)-1H-indol-1-amine hydrochloride (HP 749, I), a non-receptor-dependent cholinomimetic agent with… Expand