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HOP-92

A large cell carcinoma cell line established from lung carcinoma tissue removed from a 62 year old male.
National Institutes of Health

Papers overview

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2017
2017
Synthesis and Antiproliferative Activity of Novel Heterocyclic Indole-Trimethoxyphenyl Conjugates
The synthesis and biological evaluation of a series of novel heterocyclic indole derivatives is described. The consolidation of… 
2015
2015
Synthesis of novel amides based on acridone scaffold with interesting antineoplastic activity.
In search of novel cytotoxic agents based on acridone scaffold, twenty five derivatives of acridone-2- carboxamide were… 
2015
2015
Synthesis of N-{[5-aryl/alkyl-1,3,4-oxadiazol-2-yl]methyl}pyridin-2-amine as Antimicrobial and Anticancer Agents
A new series of oxadiazole analogues were synthesized starting from 2-aminopyridine. The compounds were characterized by infrared… 
2014
2014
New spiroindolinones bearing 5-chlorobenzothiazole moiety
Abstract In this study, 5-chloro-3H-spiro-[1,3-benzothiazole-2,3′-indole]-2′(1′H)-one derivatives 3a–l were synthesized by the… 
2013
2013
A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin
A series of substituted ethyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-5-(1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl… 
2012
2012
Chem-bioinformatics and in vitro approaches for candidate optimization: a case study of NSC745689 as a promising antitumor agent
The benzothiazole scaffold has been reported to have antitumor activity in tumor-sensitive cell lines by proposed mechanism of… 
2009
2009
N-acylated and N,N'-diacylated imidazolidine-2-thione derivatives and N,N'-diacylated tetrahydropyrimidine-2(1H)-thione analogues: synthesis and antiproliferative activity.
2009
2009
Parallel Synthesis of O‐Phenoxyethyl and O‐Adamantyl N‐acyl Thiocarbamates Endowed with Antiproliferative Activity
In order to further explore the antiproliferative properties of O‐phenoxyethyl and O‐adamantyl acylthiocarbamates (ATCs), a… 
2006
2006
Differential effect of bryostatin 1 and phorbol 12-myristate 13-acetate on HOP-92 cell proliferation is mediated by down-regulation of protein kinase Cdelta.
Bryostatin 1 is currently in clinical trials as a cancer chemotherapeutic agent. Although bryostatin 1, like phorbol 12-myristate… 
2004
2004
Induction of growth inhibition and G1 arrest in human cancer cell lines by relatively low-toxic diamantane derivatives
We describe the discovery of a novel series of antitumor diamantane derivatives which induces G1 arrest in Colo 205 cells. Eight… 
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