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HO 221

Known as: HO-221 
National Institutes of Health

Papers overview

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2004
2004
Mechanism of tumor cell killing by HO-221, a novel antitumor compound
SummaryThe mechanism of tumor cell killing by HO-221, a novel benzoylphenylurea derivative that shows broad-spectrum antitumor… 
2004
2004
Antitumor activity on murine tumors of a novel antitumor benzoylphenylurea derivative, HO-221
SummaryA novel antitumor compound,N-[4-(5-bromo-2-pyrimidinyloxy)-3-chlorophenyl]-N′-(2-nitrobenzoyl) urea (HO-221) was evaluated… 
2003
2003
Effect of novel benzoylphenylurea derivatives on DNA polymerase α activity using the synthesome-based in vitro model system
Six benzoylphenylurea (BPU) derivatives have been synthesized in Japan and extensively evaluated by the U.S. National Cancer… 
Highly Cited
1993
Highly Cited
1993
Improved oral absorption of a poorly water-soluble drug, HO-221, by wet-bead milling producing particles in submicron region.
N-[[[4-(5-Bromo-2-pyrimidinyloxy)-3-chlorophenyl]amino]carbonyl]-2 -nitrobenzamide (HO-221) is being developed as an anticancer… 
1993
1993
Pharmacokinetics of a micronized, poorly water-soluble drug, HO-221, in experimental animals.
N-[[[4-(5-Bromo-2-pyrimidinyloxy)-3-chlorophenyl]amino]carbonyl] - 2-nitrobenzamide (HO-221) is presently under development as an… 
1991
1991
[Combination chemotherapy of HO-221, a derivative of benzoylphenylurea with various anticancer agents against human cancer xenografts in nude mice].
Antitumor effect of HO-221, a derivative of benzoylphenylurea, has been previously studied against seven human cancer xenografts… 
1991
1991
[Combined effect of HO-221 with various antitumor agents against L 1210 leukemia].
Combined effect of N-[4-(5-bromo-2-pyrimidinyloxy)-3-chlorophenyl]-N'-(2-nitrobenzoyl ) urea, HO-221, with various antitumor… 
1991
1991
[Cross-resistance of HO-221 and various antitumor agents in sublines of mouse leukemia].
HO-221, N-[4-(5-bromo-2-pyrimidinyloxy)-3-chlorophenyl]-N'-(2- nitrobenzoyl) urea is a new benzoylphenylurea derivative. The… 
1990
1990
[Antitumor effect of a benzoylphenylurea derivative HO-221].
HO-221, N-[4-(5-Bromo-2-pyrimidinyloxy)-3-chlorophenyl]-N'-(2-nitrobenzoyl ) urea is a novel benzoylphenylurea derivative. We had… 
1990
1990
[Mechanism of antitumor effect of a benzoylphenylurea derivative, HO-221].
HO-221, N-[4-(5-Bromo-2-pyrimidinyloxy)-3-chlorophenyl]-N'-(2-nitrobenzoyl ) urea is a novel benzoylphenylurea derivative. We… 
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