HER2 Positive Breast Carcinoma

Known as: HER2 Overexpressing Subtype of Breast Carcinoma, HER2 Overexpressing Breast Carcinoma, HER2 Positive Breast Cancer 
A biologic subset of breast carcinoma defined by high expression of HER2, GRB7, and TRAP100, and by lack of expression of estrogen receptor (ER).
National Institutes of Health

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AC-T-T RegimenBreastEpithelial CellsEpithelium
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Highly Cited
2014
Highly Cited
2014
High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth.
MicroRNAs (miRNAs) are non-coding RNAs regulating gene expression post-transcriptionally. We have characterized the role of… (More)
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2013
2013
The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells.
About 20% of breast cancers are characterized by amplification and overexpression of the HER2 oncogene. Although significant… (More)
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Highly Cited
2009
Highly Cited
2009
Concurrent trastuzumab and HER2/neu-specific vaccination in patients with metastatic breast cancer.
PURPOSE The primary objectives of this phase I/II study were to evaluate the safety and immunogenicity of combination therapy… (More)
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Highly Cited
2007
Highly Cited
2007
Trastuzumab prolongs overall survival in patients with brain metastases from Her2 positive breast cancer
Background: Brain metastases are frequently encountered in Her2 positive advanced breast cancer. It is still not clear, if… (More)
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Highly Cited
2007
Highly Cited
2007
Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic…
Pathologic redirection of translational control by constitutive activation of eukaryotic translation initiation factor 4F (eIF4F… (More)
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Highly Cited
2007
Highly Cited
2007
Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus.
Efflux is an important resistance mechanism in Staphylococcus aureus, but its frequency in patients with bacteremia is unknown… (More)
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Highly Cited
2004
Highly Cited
2004
Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.
Breast cancer resistance protein (BCRP) is a newly identified ATP-binding cassette transporter, shown to confer multidrug… (More)
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Highly Cited
2004
Highly Cited
2004
The risk of central nervous system metastases after trastuzumab therapy in patients with breast carcinoma.
BACKGROUND Trastuzumab, which is a large monoclonal antibody that is efficacious in the treatment of patients with HER-2/neu… (More)
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Highly Cited
2003
Highly Cited
2003
Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma.
BACKGROUND Women with HER-2 overexpressing metastatic breast carcinoma benefit from trastuzumab-based therapy, but trastuzumab… (More)
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Highly Cited
1998
Highly Cited
1998
Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer…
PURPOSE To determine the toxicity, pharmacokinetics, response rate, and response duration of intravenous (i.v.) administration of… (More)
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