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HCT-116

A carcinoma cell line established from an adult male patient with colon carcinoma. HCT-116 cells have a mutation in codon 13 of the ras proto… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Ferula pseudalliacea induces apoptosis in human colorectal cancer HCT-116 cells via mitochondria-dependent pathway
Abstract Ferula species have diverse biological functions. This study set out to investigate the anti-proliferative effects of… 
2014
2014
Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors.
2012
2012
Inhibition by zinc of deoxycholate‐induced apoptosis in HCT‐116 cells
The bile acid, deoxycholate, can induce apoptosis although the effect of trace elements on such cell death is unknown. The aim of… 
2011
2011
LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression.
We recently established that LYG-202, a new flavonoid with a piperazine substitution, exerts an anti-tumor effect in vivo and in… 
2010
2010
Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells.
We studied the relationship between diosgenin-induced apoptosis and arachidonic acid metabolism in two cancer cell lines, the HT… 
Highly Cited
2008
Highly Cited
2008
Curcumin induces apoptosis in HCT-116 human colon cancer cells in a p21-independent manner.
2006
2006
Apoptosis induced by glycoprotein (150-kDa) isolated from Solanum nigrum L. is not related to intracellular reactive oxygen species (ROS) in HCT-116 cells
This study was carried out to investigate the apoptotic effects of glycoprotein [Solanum nigrum L. (SNL) glycoprotein, 150-kDa… 
2005
2005
Changes in adsorption and permeability of mitoxantrone on plasma membrane of BCRP/MXR resistant cells.
2004
2004
A 150-kDa glycoprotein isolated from Solanum nigrum L. has cytotoxic and apoptotic effects by inhibiting the effects of protein kinase C alpha, nuclear factor-kappa B and inducible nitric oxide in…
This study was carried out to investigate the anticancer effects of a 150-kDa glycoprotein isolated from Solanum nigrum L. (SNL… 
2002
2002
Mitotic arrest induced by XK469, a novel antitumor agent, is correlated with the inhibition of cyclin B1 ubiquitination
XK469 (NSC 697887) is a novel antitumor agent with broad activity against a variety of tumors. Previous studies suggest that… 
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