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HCRTR2 gene

Known as: orexin receptor 2, OREXIN RECEPTOR, OREXIN A/OREXIN B RECEPTOR 
 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
BackgroundDrugs targeting insomnia ideally promote sleep throughout the night, maintain normal sleep architecture, and are devoid… Expand
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Highly Cited
2013
Highly Cited
2013
Dual orexin receptor (OXR) antagonists (DORAs) such as almorexant, 1 (SB-649868), or suvorexant have shown promise for the… Expand
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Highly Cited
2012
Highly Cited
2012
Orexin (hypocretin) neuropeptides promote wakefulness by signaling through two G-protein coupled receptors, Orexin 1 Receptor (OX… Expand
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Highly Cited
2011
Highly Cited
2011
Abstract: Orexins/hypocretins are key neuropeptides responsible for regulating central arousal and reward circuits. Two receptors… Expand
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Highly Cited
2010
Highly Cited
2010
Orexin neurons (hypocretin neurons) have a critical role in the regulation of sleep/wakefulness, especially in the maintenance of… Expand
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Highly Cited
2010
Highly Cited
2010
Orexin is a key neurotransmitter of central arousal and reward circuits in the CNS. Two receptors respond to orexin signaling… Expand
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Highly Cited
2009
Highly Cited
2009
Recent preclinical and clinical research has shown that almorexant promotes sleep in animals and humans without disrupting the… Expand
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Highly Cited
2006
Highly Cited
2006
The G1246A polymorphism in the gene of the hypocretin receptor 2 (HCRTR2) has been linked to the risk for cluster headache (CH… Expand
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Highly Cited
2005
Highly Cited
2005
While there have been many studies in various species examining the mode of central leptin action on food intake, there is… Expand
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2002
2002
New orexigenic peptides called orexins have recently been described in the neurons of the lateral hypothalamus and perifornical… Expand
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