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HCN2 gene

Known as: hyperpolarization activated cyclic nucleotide gated potassium channel 2, BRAIN CYCLIC-NUCLEOTIDE GATED 2, BCNG-2 
National Institutes of Health

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HCN2 potassium channel

Papers overview

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2017
2017
Hyperexcitability of Mesencephalic Trigeminal Neurons and Reorganization of Ion Channel Expression in a Rett Syndrome Model
People with Rett syndrome (RTT) have defects in motor function also seen in Mecp2‐null mice. Motor function depends on not only… 
2016
2016
Expression and cellular localization of HCN channels in rat cerebellar granule neurons.
2012
2012
Molecular identity, ontogeny, and cAMP modulation of the hyperpolarization-activated current in vestibular ganglion neurons.
Properties, developmental regulation, and cAMP modulation of the hyperpolarization-activated current (I(h)) were investigated by… 
2011
2011
Energetics of Cyclic AMP Binding to HCN Channel C Terminus Reveal Negative Cooperativity*
Cyclic AMP binds to the HCN channel C terminus and variably stabilizes its open state. Using isothermal titration calorimetry, we… 
2010
2010
Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers.
New I(f) blockers have been designed and tested on HEK293 cells stably expressing the HCN1, HCN2, and HCN4 channels to find… 
2009
2009
Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells.
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate pacemaker activity in some cardiac cells and neurons… 
Highly Cited
2008
Highly Cited
2008
Direct evidence for calcium conductance of hyperpolarization-activated cyclic nucleotide-gated channels and human native If at physiological calcium concentrations.
AIMS The hyperpolarization-activated cyclic nucleotide-gated (HCN) current I(f)/I(HCN) is generally thought to be carried by Na… 
Highly Cited
2006
Highly Cited
2006
Distinct Populations of HCN Pacemaker Channels Produce Voltage-dependent and Voltage-independent Currents
Hyperpolarization-activated HCN pacemaker channels are critical for the generation of spontaneous activity and the regulation of… 
2004
2004
Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction
2001
2001
Gi- and Gs-coupled receptors up-regulate the cAMP cascade to modulate HCN2, but not HCN1 pacemaker channels
Abstract. A hallmark of native pacemaker channels is their regulation by neurotransmitters and hormones acting through the second… 
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