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HAX1 gene

Known as: HCLS1 associated protein X-1, HCLS1 (and PKD2) associated protein, HCLSBP1 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
A long noncoding RNA promotes cellulase expression in Trichoderma reesei
BackgroundDue to its capability to secrete large quantities of plant biomass degrading enzymes (PBDE), Trichoderma reesei is… 
2015
2015
Regulation of Focal Adhesion Dynamics and Cell Motility by the EB2 and Hax1 Protein Complex*
Cell migration is a fundamental cellular process requiring integrated activities of the cytoskeleton, membrane, and cell… 
Review
2014
Review
2014
Neurological findings and genetic alterations in patients with Kostmann syndrome and HAX1 mutations
To describe the clinical profile and the prevalence of severe congenital neutropenia (SCN) and HAX1 mutations, so‐called Kostmann… 
2012
2012
Cellular Protein HAX1 Interacts with the Influenza A Virus PA Polymerase Subunit and Impedes Its Nuclear Translocation
ABSTRACT Transcription and replication of the influenza A virus RNA genome occur in the nucleus through the viral RNA-dependent… 
Highly Cited
2012
Highly Cited
2012
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF–triggered granulopoiesis
We found that hematopoietic cell–specific Lyn substrate 1 (HCLS1 or HS1) is highly expressed in human myeloid cells and that… 
2010
2010
HAX1 deficiency: Impact on lymphopoiesis and B‐cell development
HAX1 was originally described as HS1‐associated protein with a suggested function in receptor‐mediated apoptotic and… 
2009
2009
Hax1 lacks BH modules and is peripherally associated to heavy membranes: implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis
Hax1 has an important role in immunodeficiency syndromes and apoptosis. A recent report (Chao et al., Nature, 2008) proposed that… 
Highly Cited
2008
Highly Cited
2008
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons
Cytokines affect a variety of cellular functions, including regulation of cell numbers by suppression of programmed cell death… 
Highly Cited
2007
Highly Cited
2007
HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)
Autosomal recessive severe congenital neutropenia (SCN) constitutes a primary immunodeficiency syndrome associated with increased… 
2007
2007
Severe developmental delay and epilepsy in a Japanese patient with severe congenital neutropenia due to HAX1 deficiency
HAX1 deficiency has recently been identified as a cause of severe congenital neutropenia (SCN), but little is known about the… 
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