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HAUS6 gene

Known as: DIM GAMMA-TUBULIN 6, DROSOPHILA, HOMOLOG OF, DGT6, FLJ20060 
 
National Institutes of Health

Papers overview

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2019
2019
We sought to identify susceptibility genes for high-grade serous ovarian cancer (HGSOC) by performing a transcriptome-wide… Expand
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2018
2018
ABSTRACT We have investigated a possible role for the inner nuclear membrane protein Samp1 (also known as TMEM201) in the mitotic… Expand
2016
2016
Congenital gliobastoma multiforme (GBM) is rare and little is known about the molecular defects underlying the initiation and… Expand
2014
2014
.................................................................................................................................. ii ACKNOWLEDGMENTS ........................................................................................................... iv LIST OF TABLES ..................................................................................................................... viii LIST OF FIGURES ..................................................................................................................... ix LIST OF APPENDICES .............................................................................................................. xi ABBREVIATIONS ..................................................................................................................... xii PROTEIN NAMES .................................................................................................................... xiv CHAPTER I: INTRODUCTION ............................................................................................... 1 1.1. The cell cycle ................................................................................................................................. 2 1.1.1. The basic principles of cell cycle regulation in eukaryotes .................................................... 2 1.1.2. The cell cycle and the centrosome cycle are intricately linked ............................................... 4 1.1.3. A network of kinases and phosphatases orchestrates mitotic processes ................................. 5 1.2. The centrosome ........................................................................................................................... 12 1.2.1. Centrosome functions and structure ...................................................................................... 12 1.2.2. The centrosome proteome ..................................................................................................... 13 1.2.3. Centrioles .............................................................................................................................. 14 1.2.3.1. Centriole architecture .................................................................................................................... 14 1.2.3.2. Centriole functions ........................................................................................................................ 15 1.2.4. The pericentriolar material (PCM) ........................................................................................ 16 1.2.5. The centrosome cycle ............................................................................................................ 25 1.2.5.1. Centriole duplication ..................................................................................................................... 25 1.2.5.2. Centrosome maturation and separation ......................................................................................... 28 1.3. The mitotic spindle ..................................................................................................................... 32 1.3.1. Microtubules are the basic elements of the mitotic spindle .................................................. 32 1.3.1.1. Astral microtubules regulate spindle positioning .......................................................................... 33 1.3.1.2. Interpolar microtubules fulfill important roles inside the mitotic spindle .................................... 34 1.3.1.3. Kinetochore microtubules are essential for chromosome segregation .......................................... 35 1.3.2. Microtubule nucleation pathways during mitotic spindle assembly ..................................... 37 1.3.2.1. RanGTP-dependent microtubule nucleation around chromatin .................................................... 38 1.3.2.2. CPC-dependent microtubule nucleation at kinetochores .............................................................. 39 1.3.2.3. Microtubule-dependent microtubule amplification within the spindle ......................................... 40 1.3.3. The role of mitotic motor and nonmotor proteins during spindle assembly ......................... 42 1.3.3.1. Mitotic motor proteins ................................................................................................................... 42 1.3.3.2. Nonmotor spindle proteins ............................................................................................................ 45 1.4. Spindle defects and human disease ........................................................................................... 49 1.4.1. Defects during spindle assembly can result in chromosome instability and aneuploidy ...... 49 1.4.2. Centrosomes are critical for asymmetric cell divisions during neurogenesis ....................... 52 1.5. Summary and rationale of my graduate work ........................................................................ 54 1.6. Figures ......................................................................................................................................... 56 
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Highly Cited
2011
Highly Cited
2011
BackgroundThere is reason to expect strong genetic influences on the risk of developing active pulmonary tuberculosis (TB) among… Expand
2011
2011
Proper assembly of mitotic spindles requires Hice1, a spindle-associated protein. Hice1 possesses direct microtubule binding… Expand
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2009
2009
In centrosome-containing cells, spindle assembly relies on microtubules (MTs) nucleated from both centrosomes and chromosomes… Expand
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2009
2009
We previously showed that FAM29A, a spindle-associated protein, promotes microtubule-dependent microtubule amplification through… Expand
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Highly Cited
2008
Highly Cited
2008
Since the discovery of γ-tubulin, attention has focused on its involvement as a microtubule nucleator at the centrosome. However… Expand
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Highly Cited
2008
Highly Cited
2008
Microtubules (MTs) are nucleated from centrosomes and chromatin. In addition, MTs can be generated from preexiting MTs in a… Expand
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