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HAS1 gene

Known as: HAS1, HYALURONAN SYNTHASE 1 
National Institutes of Health

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hyaluronan synthase 1

Papers overview

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Highly Cited
2013
Highly Cited
2013
Hyaluronan synthases (HAS1–3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival
Abstract Accumulation of hyaluronan (HA) in pericellular stroma and carcinoma cells is predictive of unfavorable patient… 
Highly Cited
2013
Highly Cited
2013
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
The naked mole rat (Heterocephalus glaber) displays exceptional longevity, with a maximum lifespan exceeding 30 years. This is… 
Highly Cited
2008
Highly Cited
2008
Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44.
Hyaluronic acid (HA) promotes tumor metastasis and is an accurate diagnostic marker for bladder cancer. HA is synthesized by HA… 
Highly Cited
2007
Highly Cited
2007
Heregulin-mediated ErbB2-ERK Signaling Activates Hyaluronan Synthases Leading to CD44-dependent Ovarian Tumor Cell Growth and Migration*
Heregulin (HRG)-induced cell responses are mediated by the ErbB family of tyrosine kinase receptors. In this study we have… 
Highly Cited
2007
Highly Cited
2007
Involvement of Hyaluronan in Regulation of Fibroblast Phenotype*
This study aimed to understand the role of the matrix polysaccharide, hyaluronan (HA), in influencing the scarring process by… 
Highly Cited
2002
Highly Cited
2002
Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration
Elevated hyaluronan biosynthesis and matrix deposition correlates with cell proliferation and migration. We ectopically expressed… 
Highly Cited
2001
Highly Cited
2001
Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.
Hyaluronan synthase 3 (HAS3) is responsible for the production of both secreted and cell-associated forms of hyaluronan and is… 
Highly Cited
2000
Highly Cited
2000
In Vitro Synthesis of Hyaluronan by a Single Protein Derived from Mouse HAS1 Gene and Characterization of Amino Acid Residues Essential for the Activity*
HAS1 was expressed as a FLAG-tagged HAS1 fusion protein in COS-1 cells. This recombinant protein was extracted with CHAPS (3-[(3… 
Highly Cited
1999
Highly Cited
1999
Three Isoforms of Mammalian Hyaluronan Synthases Have Distinct Enzymatic Properties*
Three mammalian hyaluronan synthase genes,HAS1, HAS2, and HAS3, have recently been cloned. In this study, we characterized and… 
Highly Cited
1999
Highly Cited
1999
Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells.
To investigate the roles of hyaluronan produced by cancer cells in cancer metastasis, the metastatic potential of the highly… 
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