HAS1 gene

Known as: HAS1, HYALURONAN SYNTHASE 1 
 
National Institutes of Health

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hyaluronan synthase 1

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2013
2013
Hyaluronan synthases (HAS1–3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival
Accumulation of hyaluronan (HA) in pericellular stroma and carcinoma cells is predictive of unfavorable patient prognosis in many… (More)
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2013
2013
Has1 regulates consecutive maturation and processing steps for assembly of 60S ribosomal subunits
Ribosome biogenesis requires ∼200 assembly factors in Saccharomyces cerevisiae. The pre-ribosomal RNA (rRNA) processing defects… (More)
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2012
2012
Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy.
Hyaluronic acid (HA) is a component of the extracellular matrix (ECM) in most vertebrate tissues and is thought to play a… (More)
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2011
2011
Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis.
BACKGROUND Cancer biomarkers are the backbone for the implementation of individualized approaches to bladder cancer (BCa… (More)
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2009
2009
Aberrant splice variants of HAS1 (Hyaluronan Synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential mechanism promoting human cancer.
Most human genes undergo alternative splicing, but aberrant splice forms are hallmarks of many cancers, usually resulting from… (More)
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2008
2008
Expression of Hyaluronan Synthases (HAS1–3) and Hyaluronidases (HYAL1–2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content
Hyaluronan, a tumor promoting extracellular matrix polysaccharide, is elevated in malignant epithelial ovarian tumors, and… (More)
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2004
2004
Light and metabolic regulation of HAS1, HAS1.1 and HAS2, three asparagine synthetase genes in Helianthus annuus.
The role of light, carbon and nitrogen availability on the regulation of three asparagine synthetase (AS, EC 6.3.5.4)-coding… (More)
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2000
2000
In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity.
HAS1 was expressed as a FLAG-tagged HAS1 fusion protein in COS-1 cells. This recombinant protein was extracted with CHAPS (3-[(3… (More)
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Highly Cited
2000
Highly Cited
2000
Expression of human hyaluronan synthases in response to external stimuli.
In the present study we have investigated the expression of mRNAs for hyaluronan synthase isoforms (HAS1, HAS2 and HAS3) in… (More)
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Highly Cited
1999
Highly Cited
1999
Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties.
Three mammalian hyaluronan synthase genes, HAS1, HAS2, and HAS3, have recently been cloned. In this study, we characterized and… (More)
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