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HAS1 gene
Known as:
HAS1
, HYALURONAN SYNTHASE 1
National Institutes of Health
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1 relation
hyaluronan synthase 1
Papers overview
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Highly Cited
2013
Highly Cited
2013
Hyaluronan synthases (HAS1–3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival
P. Auvinen
,
K. Rilla
,
+7 authors
R. Tammi
Breast Cancer Research and Treatment
2013
Corpus ID: 36709678
Abstract Accumulation of hyaluronan (HA) in pericellular stroma and carcinoma cells is predictive of unfavorable patient…
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Highly Cited
2013
Highly Cited
2013
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
Xiao Tian
,
J. Azpurua
,
+7 authors
A. Seluanov
2013
Corpus ID: 6068294
The naked mole rat (Heterocephalus glaber) displays exceptional longevity, with a maximum lifespan exceeding 30 years. This is…
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Highly Cited
2008
Highly Cited
2008
Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44.
R. Golshani
,
Luis E. Lopez
,
V. Estrella
,
M. Kramer
,
N. Iida
,
V. Lokeshwar
Cancer Research
2008
Corpus ID: 10532458
Hyaluronic acid (HA) promotes tumor metastasis and is an accurate diagnostic marker for bladder cancer. HA is synthesized by HA…
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Highly Cited
2007
Highly Cited
2007
Heregulin-mediated ErbB2-ERK Signaling Activates Hyaluronan Synthases Leading to CD44-dependent Ovarian Tumor Cell Growth and Migration*
L. Bourguignon
,
E. Gilad
,
K. Peyrollier
Journal of Biological Chemistry
2007
Corpus ID: 23896410
Heregulin (HRG)-induced cell responses are mediated by the ErbB family of tyrosine kinase receptors. In this study we have…
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Highly Cited
2007
Highly Cited
2007
Involvement of Hyaluronan in Regulation of Fibroblast Phenotype*
S. Meran
,
David Thomas
,
+4 authors
R. Steadman
Journal of Biological Chemistry
2007
Corpus ID: 10340639
This study aimed to understand the role of the matrix polysaccharide, hyaluronan (HA), in influencing the scarring process by…
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Highly Cited
2002
Highly Cited
2002
Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration
N. Itano
,
F. Atsumi
,
+5 authors
K. Kimata
Proceedings of the National Academy of Sciences…
2002
Corpus ID: 11502592
Elevated hyaluronan biosynthesis and matrix deposition correlates with cell proliferation and migration. We ectopically expressed…
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Highly Cited
2001
Highly Cited
2001
Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.
N. Liu
,
F. Gao
,
Z. Han
,
X. Xu
,
C. Underhill
,
L. Zhang
Cancer Research
2001
Corpus ID: 10900375
Hyaluronan synthase 3 (HAS3) is responsible for the production of both secreted and cell-associated forms of hyaluronan and is…
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Highly Cited
2000
Highly Cited
2000
In Vitro Synthesis of Hyaluronan by a Single Protein Derived from Mouse HAS1 Gene and Characterization of Amino Acid Residues Essential for the Activity*
M. Yoshida
,
N. Itano
,
Y. Yamada
,
K. Kimata
Journal of Biological Chemistry
2000
Corpus ID: 38594709
HAS1 was expressed as a FLAG-tagged HAS1 fusion protein in COS-1 cells. This recombinant protein was extracted with CHAPS (3-[(3…
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Highly Cited
1999
Highly Cited
1999
Three Isoforms of Mammalian Hyaluronan Synthases Have Distinct Enzymatic Properties*
N. Itano
,
T. Sawai
,
+11 authors
K. Kimata
Journal of Biological Chemistry
1999
Corpus ID: 22477026
Three mammalian hyaluronan synthase genes,HAS1, HAS2, and HAS3, have recently been cloned. In this study, we characterized and…
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Highly Cited
1999
Highly Cited
1999
Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells.
N. Itano
,
T. Sawai
,
O. Miyaishi
,
K. Kimata
Cancer Research
1999
Corpus ID: 21010052
To investigate the roles of hyaluronan produced by cancer cells in cancer metastasis, the metastatic potential of the highly…
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