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H 142

Known as: H-142, L-Lysine, N2-(N-(N-(N-(4-methyl-2-((N-(N-(1-(N-L-prolyl-L-histidyl)-L-prolyl)-L-phenylalanyl)-L-histidyl)amino)pentyl)-L-valyl)-L-isoleucyl)-L-histidyl)-, (S)- 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Angiotensinogen

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1993
Highly Cited
1993
2-substituted quinoline alkaloids as potential antileishmanial drugs
Ten 2-substituted quinoline alkaloids isolated from a plant used for treatment of New World cutaneous leishmaniasis have… 
1991
1991
Vascular production and regulation of angiotensin.
To test the hypothesis that angiotensin (Ang) I and II are produced by blood vessels, we investigated the formation of both Ang I… 
Highly Cited
1989
Highly Cited
1989
Angiotensin formation in the isolated rat hindlimb.
Local vascular generation of angiotensin was investigated in isolated perfused rat hindquarters. Extraction and combined high… 
Highly Cited
1987
Highly Cited
1987
High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes
Inhibitors of the conversion of angiotensinogen to the vasoconstrictor angiotensin II have considerable value as antihypertensive… 
1985
1985
Energy calculations on aspartic proteinases: human renin, endothiapepsin and its complex with an angiotensinogen fragment analogue, H-142.
The rational design of inhibitors of human renin for the treatment of hypertension depends on a detailed knowledge of the renin… 
1985
1985
Design, synthesis and analysis of new synthetic substrates for the aspartic proteinases.
  • B. DunnJ. Kay
  • Biochemical Society Transactions
  • 1985
  • Corpus ID: 27369640
certainty although its general position is reasonably well defined. In the energy refinement, this part of the structure… 
1984
1984
Angiotensin I-generating acid endopeptidase activity in neurosecretory vesicles isolated from bovine pituitary
1983
1983
REDUCTION OF BLOOD PRESSURE IN MAN WITH H-142, A POTENT NEW RENIN INHIBITOR
1983
1983
Inhibition of renin in the primate Callithrix jacchus (common marmoset).
The effects of an antiserum against human kidney renin and of H-142, a peptide inhibitor of human renin, were studied in the… 
Highly Cited
1982
Highly Cited
1982
Potent new inhibitors of human renin
The renal acid protease renin selectively cleaves its plasma substrate angiotensinogen to release the decapeptide angiotensin I… 
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