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Gossypol

Known as: (+/-)-Gossypol, Gossypol [Chemical/Ingredient], 2,2'-bis[1,6,7-Trihydroxy-4-methyl-5-isopropyl-8-aldehydonaphthalene 
An orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cell… 
National Institutes of Health

Related topics

Related topics

39 relations

Narrower (17)

1,1'-dideoxygossypol6-aminopenicillanic acid gossypoloneAT 101BI112D1

Broader (6)

Antispermatogenic AgentsContraceptive Agents, MaleNaphtholsPlant alkaloid
BL-193Cottonseed OilGossypiumGossypol.negative isomer:MCnc:Pt:XXX:Qn

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
A preliminary clinical study of gossypol in advanced human cancer
SummaryA total of 34 patients with advanced cancer were given weekly or daily escalating doses of oral gossypol, a cottonseed-oil… 
Highly Cited
2002
Highly Cited
2002
Toxicity of (+)- and (-)-gossypol to the plant pathogen, Rhizoctonia solani.
The dimeric sesquiterpene gossypol occurs naturally in cottonseed and other parts of the cotton plant. Gossypol exists as… 
Highly Cited
1994
Highly Cited
1994
Growth and reproductive development in Brahman bulls fed diets containing gossypol.
To determine the effect of gossypol on growth and reproductive development, Brahman bulls (n = 30) were fed diets containing… 
1993
1993
Demonstration of a novel type of ATP-diphosphohydrolase (EC 3.6.1.5) in the bovine lung.
Highly Cited
1987
Highly Cited
1987
Stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor from cultured endothelial cells.
Highly Cited
1984
Highly Cited
1984
Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines.
Gossypol, a yellow pigment from the cotton plant (Gossypium) was found to have anti-tumor cell effects against several tumor cell… 
Highly Cited
1984
Highly Cited
1984
Effect of gossypol on DNA synthesis and cell cycle progression of mammalian cells in vitro.
Gossypol, a yellow phenolic compound extracted from cotton plants that is being used as a male antifertility drug, has been found… 
Highly Cited
1983
Highly Cited
1983
Inhibition of the A-23187-stimulated leukotriene and prostaglandin biosynthesis of rat basophil leukemia (RBL-1) cells by nonsteroidal anti-inflammatory drugs, antioxidants, and calcium channel…
Highly Cited
1965
Highly Cited
1965
Determination of free and bound gossypol in swine tissues
Methods have been developed for the determination of free and bound gossypol in the tissues of swine ingesting diets containing… 
Highly Cited
1957
Highly Cited
1957
The pathology of gossypol poisoning.
The toxic effects of prolonged ingestion of cottonseed meal were recognized in animals as early as i9ii.1 Since this substance is… 
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