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Glycogen Synthase Kinases

Known as: Glycogen Synthase Kinase, Kinases, Glycogen Synthase, Synthase Kinase, Glycogen 
A class of protein-serine-threonine kinases that was originally found as one of the three types of kinases that phosphorylate GLYCOGEN SYNTHASE… 
National Institutes of Health

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In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Papers overview

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Highly Cited
2008
Highly Cited
2008
Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells.
Phosphoinositide 3-kinase (PI3K) negatively regulates Toll-like receptor (TLR)-mediated interleukin-12 (IL-12) expression in… 
Highly Cited
2007
Highly Cited
2007
Glycogen Synthase Kinase 3 Phosphorylates Hypoxia-Inducible Factor 1α and Mediates Its Destabilization in a VHL-Independent Manner
ABSTRACT Hypoxia-inducible transcription factor 1α (HIF-1α) is a key player in the response to hypoxia. Additionally, HIF-1… 
Highly Cited
2007
Highly Cited
2007
Muscle-Specific Deletion of Rictor Impairs Insulin-Stimulated Glucose Transport and Enhances Basal Glycogen Synthase Activity
ABSTRACT Rictor is an essential component of mTOR (mammalian target of rapamycin) complex 2 (mTORC2), a kinase complex that… 
Highly Cited
2005
Highly Cited
2005
Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3
A wide range of agents and conditions are known to disrupt the ability of the endoplasmic reticulum (ER) to fold proteins… 
Highly Cited
2003
Highly Cited
2003
Structural basis for recruitment of glycogen synthase kinase 3β to the axin—APC scaffold complex
Glycogen synthase kinase 3β (GSK3β) is a serine/threonine kinase involved in insulin, growth factor and Wnt signalling. In Wnt… 
Highly Cited
2003
Highly Cited
2003
Regulation of Hypoxia-inducible Factor-1α Protein Level during Hypoxic Conditions by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Pathway in HepG2 Cells*
Hypoxia initiates an intracellular signaling pathway leading to the activation of the transcription factor hypoxia-inducible… 
Highly Cited
2002
Highly Cited
2002
Reelin-mediated Signaling Locally Regulates Protein Kinase B/Akt and Glycogen Synthase Kinase 3β*
Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor… 
Highly Cited
1999
Highly Cited
1999
The Role of Glycogen Synthase Kinase 3β in Insulin-stimulated Glucose Metabolism*
To characterize the contribution of glycogen synthase kinase 3β (GSK3β) inactivation to insulin-stimulated glucose metabolism… 
Highly Cited
1998
Highly Cited
1998
Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β
Highly Cited
1997
Highly Cited
1997
Three-Dimensional Structure of the Armadillo Repeat Region of β-Catenin
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