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Gleason Pattern 4 (classification)

Known as: Gleason Grade 4, Gleason Pattern 4 
A pattern of prostate carcinoma characterized by the presence of fused, cribriform, or poorly defined glands. There is partial loss of normal… Expand
National Institutes of Health

Papers overview

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Review
2016
Review
2016
The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System
In November, 2014, 65 prostate cancer pathology experts, along with 17 clinicians including urologists, radiation oncologists… Expand
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2016
2016
Gleason grade 4 prostate adenocarcinoma patterns: an interobserver agreement study among genitourinary pathologists.
AIMS To assess the interobserver reproducibility of individual Gleason grade 4 growth patterns. METHODS AND RESULTS Twenty… Expand
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2015
2015
Not all gleason pattern 4 prostate cancers are created equal: A study of latent prostatic carcinomas in a cystoprostatectomy and autopsy series.
BACKGROUND The Gleason grading system represents the cornerstone of the management of prostate cancer. Gleason grade 4 (G4) is a… Expand
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Highly Cited
2014
Highly Cited
2014
Gleason Score 3 + 4=7 Prostate Cancer With Minimal Quantity of Gleason Pattern 4 on Needle Biopsy Is Associated With Low-risk Tumor in Radical Prostatectomy Specimen
A modified Gleason grading system as proposed in the 2005 International Society of Urological Pathology (ISUP) consensus meeting… Expand
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Highly Cited
2013
Highly Cited
2013
Clonal progression of prostate cancers from Gleason grade 3 to grade 4.
Low-grade prostate cancers (Gleason pattern 3, G3) detected on needle biopsies are generally viewed as indolent and suitable for… Expand
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Review
2010
Review
2010
An update of the Gleason grading system.
PURPOSE An update is provided of the Gleason grading system, which has evolved significantly since its initial description… Expand
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2009
2009
Gleason grading of prostatic adenocarcinoma with glomeruloid features on needle biopsy.
Glomerulations in prostatic adenocarcinoma are characterized by dilated glands containing intraluminal cribriform structures with… Expand
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Highly Cited
2008
Highly Cited
2008
Low testosterone and risk of biochemical recurrence and poorly differentiated prostate cancer at radical prostatectomy.
OBJECTIVES To evaluate, in a prospective study, the association between low testosterone and pathologic endpoints and the risk of… Expand
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Highly Cited
2006
Highly Cited
2006
Evidence for a biopsy derived grade artifact among larger prostate glands.
PURPOSE The PCPT has demonstrated a higher incidence of high grade (Gleason pattern 4 or greater) prostate cancers among men… Expand
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Highly Cited
2002
Highly Cited
2002
Down-regulation of CEACAM1 in human prostate cancer: correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition.
Many cancers have altered expression of various cell adhesion molecules. One of these is CEACAM1, which has been found to be… Expand
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