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Gene Products, nef

Known as: nef Gene Product, NEF Protein, 3' orf Protein 
Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the… 
National Institutes of Health

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GST-Nef protein, recombinant
Genes, ViralHIV Long Terminal RepeatIn BloodProcess of secretion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
The intrinsically disordered cytoplasmic domain of the T cell receptor zeta chain binds to the nef protein of simian immunodeficiency virus without a disorder-to-order transition.
Intrinsically disordered proteins are thought to undergo coupled binding and folding upon interaction with their folded partners… 
Highly Cited
2004
Highly Cited
2004
Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus.
Atraumatic application of attenuated SIVmac239 Delta nef vaccine to the tonsils of rhesus macaques provided protection against… 
2002
2002
Effects of HIV-1 Nef on cellular gene expression profiles.
The early human immunodeficiency virus (HIV) accessory protein Nef makes an important contribution to virulence, but the… 
Highly Cited
1999
Highly Cited
1999
Induction of interleukin-15 production by HIV-1 nef protein: a role in the proliferation of uninfected cells.
Several recent reports have provided evidence that Nef enhances human immunodeficiency virus HIV infectivity, and in vitro… 
Highly Cited
1999
Highly Cited
1999
Cutting edge: induction of enhanced CTL-dependent protective immunity in vivo by N-end rule targeting of a model tumor antigen.
There is much interest in vaccines that will enhance the induction of CTL. One mechanism to enhance Ag-specific CTL responses… 
1995
1995
In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/threonine protein kinase.
Although the human immunodeficiency virus type 1 (HIV-1) nef gene still has no precisely defined function, in vivo studies have… 
Highly Cited
1993
Highly Cited
1993
The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4
The nef gene product of human immunodeficiency virus type 1 has been shown to induce CD4 downregulation from the surface of human… 
Highly Cited
1990
Highly Cited
1990
Constitutive expression of human immunodeficiency virus (HIV) nef protein in human astrocytes does not influence basal or induced HIV long terminal repeat activity
Since human immunodeficiency virus (HIV) nef has been suggested to exert regulatory effects on HIV long terminal repeat (LTR… 
1990
1990
Antibodies to HIV-1 nef(p27): prevalence, significance, and relationship to seroconversion.
A sensitive and specific enzyme-linked immunoassay for antibodies to the human immunodeficiency virus type 1 (HIV-1) nef gene… 
Highly Cited
1989
Highly Cited
1989
Antibodies to the nef protein and to nef peptides in HIV-1-infected seronegative individuals.
The silent period that follows infection by the human immunodeficiency virus (HIV-1) and precedes seroconversion remains a… 
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