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GYLTL1B gene

Known as: GLYCOSYLTRANSFERASE-LIKE 1B, FLJ35207, GYLTL1B 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer
Background Wnt signaling drives epithelial self-renewal and disease progression in human colonic epithelium and colorectal cancer… 
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2016
2016
LARGE2-dependent glycosylation confers laminin-binding ability on proteoglycans
Both LARGE1 (formerly LARGE) and its paralog LARGE2 are bifunctional glycosyltransferases with xylosy- and glucuronyltransferase… 
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2015
2015
The glycosyltransferase LARGE2 is repressed by Snail and ZEB1 in prostate cancer
Reductions in both expression of the dystroglycan core protein and functional glycosylation of the α-dystroglycan (αDG) subunit… 
2015
2015
Downregulation of dystroglycan glycosyltransferases LARGE2 and ISPD associate with increased mortality in clear cell renal cell carcinoma
BackgroundDystroglycan (DG) is a cell-surface laminin receptor that links the cytoskeleton to the extracellular matrix in a… 
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2014
2014
Endogenous Glucuronyltransferase Activity of LARGE or LARGE2 Required for Functional Modification of α-Dystroglycan in Cells and Tissues*
Background: Glycosyltransferase activities of LARGE are required for α-dystroglycan function. Results: This study reveals that… 
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2013
2013
LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE.
LARGE (like-glycosyltransferase) and LARGE2 (glycosyltransferase-like 1B (GYLTL1B)) are homologous Golgi glycosyltransferases… 
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2013
2013
Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2
LARGE-dependent modification enables α-dystroglycan (α-DG) to bind to its extracellular matrix ligands. Mutations in the LARGE… 
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2012
2012
Loss of LARGE2 Disrupts Functional Glycosylation of α-Dystroglycan in Prostate Cancer*
Background: Dystroglycan function is decreased in prostate and other cancers. Results: Decreased functional glycosylation of… 
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Highly Cited
2005
Highly Cited
2005
Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies.
The Large(myd) mouse has a loss-of-function mutation in the putative glycosyltransferase gene Large. Mutations in the human… 
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2005
2005
LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE.
The LARGE gene is thought to encode a putative glycosyltransferase because of its typical topology. However, no enzyme activity… 
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