Skip to search formSkip to main contentSkip to account menu

GYLTL1B gene

Known as: GLYCOSYLTRANSFERASE-LIKE 1B, FLJ35207, GYLTL1B 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer
Wnt signaling drives epithelial self-renewal and disease progression in human colonic epithelium and colorectal cancer (CRC… 
2016
2016
LARGE2-dependent glycosylation confers laminin-binding ability on proteoglycans
Both LARGE1 (formerly LARGE) and its paralog LARGE2 are bifunctional glycosyltransferases with xylosy- and glucuronyltransferase… 
2015
2015
The glycosyltransferase LARGE2 is repressed by Snail and ZEB1 in prostate cancer
Reductions in both expression of the dystroglycan core protein and functional glycosylation of the α-dystroglycan (αDG) subunit… 
2014
2014
Endogenous Glucuronyltransferase Activity of LARGE or LARGE2 Required for Functional Modification of α-Dystroglycan in Cells and Tissues*
Background: Glycosyltransferase activities of LARGE are required for α-dystroglycan function. Results: This study reveals that… 
2013
2013
LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE.
LARGE (like-glycosyltransferase) and LARGE2 (glycosyltransferase-like 1B (GYLTL1B)) are homologous Golgi glycosyltransferases… 
2012
2012
Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2
LARGE-dependent modification enables α-dystroglycan (α-DG) to bind to its extracellular matrix ligands. Mutations in the LARGE… 
2012
2012
Loss of LARGE2 Disrupts Functional Glycosylation of α-Dystroglycan in Prostate Cancer*
Background: Dystroglycan function is decreased in prostate and other cancers. Results: Decreased functional glycosylation of… 
2012
2012
Abstract 439: Glycosylation of α-dystroglycan in prostate cancer: Prognostic implications and regulation by LARGE2
Cancer cells exhibit altered interactions with their extracellular matrix microenvironment that are thought to underlie tumor… 
2005
2005
LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE.
The LARGE gene is thought to encode a putative glycosyltransferase because of its typical topology. However, no enzyme activity… 
Highly Cited
2005
Highly Cited
2005
Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies.
The Large(myd) mouse has a loss-of-function mutation in the putative glycosyltransferase gene Large. Mutations in the human… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)