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Tankyrases (TNKS1 and TNKS2) are members of the human poly(ADP-ribose) polymerase (PARP) family and catalyze PARsylation by using… Expand BACKGROUND
GW843682X is a publicly available anti-cancer compound by inhibiting Polo-like kinase. Previous studies revealed that… Expand In the decades since the introduction of platinum-etoposide, treatment of small cell lung cancer (SCLC) remains virtually… Expand Polo-like kinases (PLKs) have been reported to be essential components of anti-viral pathways. However, the role of PLKs in the… Expand Polo-like kinase 1 (PLK1) is a regulator of mitosis and its upregulation in tumours is often associated with poor prognosis… Expand AMP-activated protein kinase (AMPK) is being primarily studied as a central metabolic stress sensor, which regulates cell… Expand ABSTRACT Polo-like kinase in Trypanosoma brucei (TbPLK) is confined to the flagellum attachment zone (FAZ) and regulates only… Expand Objectives: Polo-like kinase1 (PLK1) belongs to the family of serine/threonine kinases and plays an important role in centrosome… Expand Polo-Kinase 1 (PLK1) is a key cell cycle regulator that is necessary for checkpoint recovery after DNA damage-induced G2 arrest… Expand