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GW843682X

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Abstract 1119: Targeting tankyrases as a therapeutic strategy for triple-negative breast cancer
Tankyrases (TNKS1 and TNKS2) are members of the human poly(ADP-ribose) polymerase (PARP) family and catalyze PARsylation by using… 
2016
2016
The cytotoxic effect of GW843682X on nasopharyngeal carcinoma.
BACKGROUND GW843682X is a publicly available anti-cancer compound by inhibiting Polo-like kinase. Previous studies revealed that… 
2016
2016
Abstract LB-170: Unique microRNA signatures in small cell lung cancer correlate with distinct protein expression profiles and drug response
In the decades since the introduction of platinum-etoposide, treatment of small cell lung cancer (SCLC) remains virtually… 
2013
2013
Polo-Like Kinase 1 (PLK1) Is Involved in Toll-like Receptor (TLR)-Mediated TNF-α Production in Monocytic THP-1 Cells
Polo-like kinases (PLKs) have been reported to be essential components of anti-viral pathways. However, the role of PLKs in the… 
2011
2011
An in-vitro evaluation of the polo-like kinase inhibitor GW843682X against paediatric malignancies
Polo-like kinase 1 (PLK1) is a regulator of mitosis and its upregulation in tumours is often associated with poor prognosis… 
2011
2011
Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus
AMP-activated protein kinase (AMPK) is being primarily studied as a central metabolic stress sensor, which regulates cell… 
2010
2010
Polo-Like Kinase Guides Cytokinesis in Trypanosoma brucei through an Indirect Means
ABSTRACT Polo-like kinase in Trypanosoma brucei (TbPLK) is confined to the flagellum attachment zone (FAZ) and regulates only… 
Highly Cited
2009
Highly Cited
2009
A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies
Objectives: Polo-like kinase1 (PLK1) belongs to the family of serine/threonine kinases and plays an important role in centrosome… 
2008
2008
Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia.
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