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National Institutes of Health
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Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?
Mukundan Baskar Mannargudi
Journal of Cancer Research and Clinical Oncology
Corpus ID: 1237456
PurposeRibonucleotide reductase (RR) enzymes (RR1 and RR2) play an important role in the reduction of ribonucleotides to…
GTI-2501, an antisense agent targeting R1, the large subunit of human ribonucleotide reductase, shows potent anti-tumor activity against a variety of tumors.
International journal of oncology
Corpus ID: 30751090
GTI-2501 is a 20-mer oligonucleotide that is complementary to a coding region in the mRNA of R1, the large subunit of…
Dose escalation phase of a phase I/II study of GTI-2501, an antisense to the R1 subunit of ribonucleotide reductase (RNR) and docetaxel in patients with metastatic hormone-refractory prostate cancer.
Journal of clinical oncology : official journal…
Corpus ID: 37144681
2078 Background: GTI-2501 (GTI) is a 20-mer oligonucleotide that is complementary to the R1 subunit of the RNR mRNA. The R1…
GTI-2501. Lorus Therapeutics.
Current opinion in investigational drugs
Corpus ID: 52312
Lorus Therapeutics (formerly GeneSense Technologies) is developing GTI-2501, directed against the R1 component of ribonucleotide…
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