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GSK598809

National Institutes of Health

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2 relations

Broader (2)

Azabicyclo CompoundsOxazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Acute D 3 Antagonist GSK 598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence
Anna Murphy*, Liam J Nestor, John McGonigle, Louise Paterson, Venkataramana Boyapati, Karen D Ersche, Remy Flechais, Shankar… 
2017
2017
Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence
This corrects the article DOI: 10.1038/npp.2016.289 
2015
2015
Dopamine D3 Receptor Antagonist (GSK598809) Potentiates the Hypertensive Effects of Cocaine in Conscious, Freely-Moving Dogs
The chronic and relapsing nature of addiction presents unique challenges for ensuring the safety of a potential medication. A… 
2015
2015
The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description
Drug and alcohol dependence are global problems with substantial societal costs. There are few treatments for relapse prevention… 
Highly Cited
2013
Highly Cited
2013
Occupancy of Brain Dopamine D3 Receptors and Drug Craving: A Translational Approach
Selective dopamine D3 receptor (D3R) antagonists prevent reinstatement of drug-seeking behavior and decrease the rewarding… 
Review
2012
Review
2012
Medication discovery for addiction: translating the dopamine D3 receptor hypothesis.
Highly Cited
2012
Highly Cited
2012
The effects of the dopamine D₃ receptor antagonist GSK598809 on attentional bias to palatable food cues in overweight and obese subjects.
The mesolimbic dopamine system plays a critical role in the reinforcing effects of rewards. Evidence from pre-clinical studies… 
2012
2012
Effect of dopamine D3 receptor antagonism on approach responses to food cues in overweight and obese individuals
The aim of the study was to examine the effect of manipulating the brain dopamine system, using a D3 receptor antagonist, on… 
2012
2012
Pharmacokinetics and central nervous system effects of the novel dopamine D3 receptor antagonist GSK598809 and intravenous alcohol infusion at pseudo-steady state
GSK598809 is a novel selective dopamine D3 receptor antagonist, currently in development for the treatment of substance abuse and… 
Highly Cited
2010
Highly Cited
2010
Imaging Dopamine D3 Receptors in the Human Brain with Positron Emission Tomography, [11C]PHNO, and a Selective D3 Receptor Antagonist
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