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GSK2251052
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
In Vitro and In Vivo Activities of DS86760016, a Novel Leucyl-tRNA Synthetase Inhibitor for Gram-Negative Pathogens
K. Purnapatre
,
M. Rao
,
+5 authors
Nobuhisa Masuda
Antimicrobial Agents and Chemotherapy
2018
Corpus ID: 46853018
ABSTRACT The emergence of multidrug-resistant (MDR) Gram-negative bacilli is a major concern in the treatment of nosocomial…
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2016
2016
A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureus
A. Gupta
,
C. Monteferrante
,
+7 authors
A. O’Neill
Antimicrobial Agents and Chemotherapy
2016
Corpus ID: 41893260
ABSTRACT GSK2251052 is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS) that has been evaluated in…
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Highly Cited
2014
Highly Cited
2014
Bacterial Resistance to Leucyl-tRNA Synthetase Inhibitor GSK2251052 Develops during Treatment of Complicated Urinary Tract Infections
Karen O'dwyer
,
Aaron Spivak
,
+16 authors
J. R. Brown
Antimicrobial Agents and Chemotherapy
2014
Corpus ID: 10178642
ABSTRACT GSK2251052, a novel leucyl-tRNA synthetase (LeuRS) inhibitor, was in development for the treatment of infections caused…
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2013
2013
Comparative In Vitro Activities of GSK2251052, a Novel Boron-Containing Leucyl-tRNA Synthetase Inhibitor, against 916 Anaerobic Organisms
E. Goldstein
,
D. Citron
,
K. Tyrrell
,
C. Merriam
Antimicrobial Agents and Chemotherapy
2013
Corpus ID: 34832589
ABSTRACT We studied the comparative in vitro activity of GSK2251052, a novel boron leucyl-tRNA synthetase inhibitor, against 916…
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2013
2013
Disposition and Metabolism of GSK2251052 in Humans: A Novel Boron-Containing Antibiotic
G. Bowers
,
David Tenero
,
+13 authors
J. Tomayko
Drug Metabolism and Disposition
2013
Corpus ID: 5574466
(S)-3-(Aminomethyl)-7-(3-hydroxypropoxy)-1-hydroxy-1,3-dihydro-2,1-benzoxaborole (GSK2251052) is a novel boron-containing…
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2013
2013
Determination of disk diffusion and MIC quality control guidelines for GSK2251052: a novel boron-containing antibacterial.
J. E. Ross
,
N. Scangarella-Oman
,
R. Jones
Diagnostic microbiology and infectious disease
2013
Corpus ID: 26769700
GSK2251052 is a boron-containing antimicrobial agent in clinical development for the treatment of serious Gram-negative bacterial…
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2013
2013
Intrapulmonary Pharmacokinetics of GSK2251052 in Healthy Volunteers
David Tenero
,
G. Bowers
,
+5 authors
P. Patel
Antimicrobial Agents and Chemotherapy
2013
Corpus ID: 25593638
ABSTRACT The plasma and intrapulmonary pharmacokinetics (PK) of intravenous (i.v.) GSK2251052, a novel boron-containing…
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2013
2013
Disposition and Metabolism of GSK 2251052 in Humans : A Novel Boron-Containing Antibiotic s
G. Bowers
,
David Tenero
,
+14 authors
J. Tomayko
2013
Corpus ID: 26139947
(S)-3-(Aminomethyl)-7-(3-hydroxypropoxy)-1-hydroxy-1,3-dihydro2,1-benzoxaborole (GSK2251052) is a novel boron-containing…
Expand
2013
2013
Intrapulmonary pharmacokinetics of GSK 2251052 in Healthy Volunteers
David Tenero
,
G. Bowers
,
+4 authors
Parul C Patel
2013
Corpus ID: 42951006
10 Running Title: Pulmonary and Plasma PK of GSK2251052 11 12 13 # Corresponding author: Parul Patel, Pharm.D. 14 GlaxoSmithKline…
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2011
2011
GSK2251052, a Novel Boron-containing Protein Synthesis Inhibitor, with Comparative in vitro Activity against Pseudomonas aeruginosa from a Global Population
S. Bouchillon
,
M. Hackel
,
D. Hoban
,
S. Hawser
,
N. Scangarella-Oman
2011
Corpus ID: 86015311
Background: GSK2251052 (formerly AN3365), a novel boron-containing leucyl-tRNA synthetase inhibitor with in vitro activity…
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