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GSK1059615

National Institutes of Health

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PI3K Inhibitor GSK1059615

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2019
2019
Glucose restriction reverses the Warburg effect and modulates PKM2 and mTOR expression in breast cancer cell lines.
Aerobic glycolysis, known as the "Warburg effect", is one of several hallmarks of cancer cells. The conversion of… 
2013
2013
Abstract 2388: Genetic determinants of sensitivity and resistance to PI3K inhibitors in head and neck cancers for efficient targeted therapy.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Head and neck squamous cell carcinoma (HNSCC) is the… 
2008
2008
In vitro sensitivity data suggests targeting several tumor types and molecular subtypes with the PI3K inhibitor GSK1059615 could maximize response rates in early clinical trials
B37 The phosphoinositide 3-kinase (PI3K) signalling pathway is activated in a broad spectrum of human cancer. Activation of this… 
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