GSAP gene

Known as: gamma-secretase activating protein, PION, GAMMA-SECRETASE-ACTIVATING PROTEIN 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1962-2017
05101519622017

Papers overview

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2015
2015
Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's disease.
BACKGROUND A major feature of Alzheimer's disease (AD) is the accumulation of amyloid-beta (Aβ), whose formation is regulated by… (More)
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2014
2014
Pharmacological modulation of GSAP reduces amyloid-β levels and tau phosphorylation in a mouse model of Alzheimer's disease with plaques and tangles.
Accumulation of neurotoxic amyloid-β (Aβ) is a major hallmark of Alzheimer's disease (AD) pathology and an important player in… (More)
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2014
2014
Common GSAP promoter variant contributes to Alzheimer's disease liability.
Toxic amyloid-β40-42 (Aβ40-42) peptide cleaved from Aβ protein precursor by β- and γ secretases plays a crucial role in the… (More)
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2013
2013
The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.
γ-Secretase is a large enzyme complex comprising presenilin, nicastrin, presenilin enhancer 2, and anterior pharynx-defective 1… (More)
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2012
2012
Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.
AIMS A recent study showed that γ-secretase activating protein (GSAP), derived from a C-terminal fragment of pigeon homolog (PION… (More)
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2012
2012
Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.
The transmembrane protease complex γ-secretase is responsible for the generation of the neurotoxic amyloid β-peptide (Aβ) from… (More)
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2012
2012
Purification and characterization of the human γ-secretase activating protein.
Alzheimer's disease is a fatal neurological disorder that is a leading cause of death, with its prevalence increasing as the… (More)
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2010
2010
THE EUROPEAN PHYSICAL JOURNAL A Pionic deuterium
The strong-interaction shift πD 1s and broadening Γ πD 1s in pionic deuterium have been determined in a high statistics study of… (More)
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2010
2010
Gamma-secretase activating protein, a therapeutic target for Alzheimer's disease
Accumulation of neurotoxic amyloid-β is a major hallmark of Alzheimer’s disease. Formation of amyloid-β is catalysed by… (More)
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1997
1997
Chiral two-loop pion-pion scattering parameters from crossing-symmetric constraints
  • G. Wanders
  • 1997
Constraints on the parameters in the oneand two-loop pion-pion scattering amplitudes of standard chiral perturbation theory are… (More)
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