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GS-458967

National Institutes of Health

Papers overview

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Review
2019
Review
2019
Point of view: Electrophysiological endpoints differ when comparing the mode of action of highly successful anti-arrhythmic drugs in the CAVB dog model with TdP.
In the anaesthetized, chronic atrioventricular block (CAVB) dog, ventricular ectopic beats and Torsade de pointes arrhythmias… 
2018
2018
ICaL and Ito mediate rate-dependent repolarization in rabbit atrial myocytes
Rate-dependent repolarization (RDR) of action potential (AP) in cardiomyocyte plays a critical role in the genesis of arrhythmias… 
2017
2017
ICaL and Ito mediate rate-dependent repolarization in rabbit atrial myocytes
Rate-dependent repolarization (RDR) of action potential (AP) in cardiomyocyte plays a critical role in the genesis of arrhythmias… 
2016
2016
Mechanisms of Diastolic Dysfunction in Cardiovascular Disease Inhibition of late Na current , a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats
Chi L, Belardinelli L, Zeng A, Hirakawa R, Rajamani S, Ling H, Dhalla AK. Inhibition of late Na current, a novel target to… 
2015
2015
Selective late INa inhibition by GS-458967 exerts parallel suppression of catecholamine-induced hemodynamically significant ventricular tachycardia and T-wave alternans in an intact porcine model.
2014
2014
Selective Inhibition of the Late Sodium Current has No Adverse Effect on Electrophysiological or Contractile Function of the Normal Heart
Abstract: Inhibition of cardiac late Na+ current (INa,L) decreases sodium-dependent calcium overload in diseased hearts. Because… 
2014
2014
Abstract 15303: GS-458967, a Selective Late Sodium Current Inhibitor, Prohibits Torsades de Pointes Arrhythmias in the Chronic Atrioventricular Block Dog Model
Introduction: GS-458967 (GS) is a novel selective and highly potent late sodium current (INaL) inhibitor. Hypothesis: GS was… 
2013
2013
GS967, By Blocking the Late Sodium Current (INaL), Has Strong Action Potential–Stabilizing Properties in Isolated Remodeled Ventricular Canine Cells
2013
2013
Selective Inhibition of Endogenous Late Na+ Current Stabilizes Cardiac Repolarization and Prevents Arrhythmogenicity
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