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GRP1 protein, Ciona intestinalis

Known as: CiGRP1 protein, Ciona intestinalis, glycine-rich RNA binding protein, Ciona intestinalis 
National Institutes of Health

Papers overview

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2018
2018
In embryos, multipotent progenitors divide to produce distinct progeny and express their full potential. In vertebrates… 
2018
2018
Ascidian embryos have been employed as model systems for studies of developmental biology for well over a century, owing to their… 
2017
2017
Invasive species offer good models for studying mechanisms of response to rapid changing environments in the wild. DNA… 
Review
2017
Review
2017
................................................................................................................................................................ 5 RIASSUNTO ............................................................................................................................................................... 8 GENERAL INTRODUCTION ................................................................................................................................ 11 1. CRANIO-FACIAL DEFECTS ................................................................................................................... 12 2. CRANIOFACIAL DEVELOPMENT ........................................................................................................ 13 3. AZOLE FUNGICIDES TERATOLOGY .................................................................................................. 20 4. ETHANOL TERATOLOGY ...................................................................................................................... 25 5. STATE OF THE ART ON THE RISK ASSESSMENT FROM EXPOSURE TO MIXTURES OF CHEMICALS .............................................................................................................................................. 27 6. ALTERNATIVE MODELS IN DEVELOPMENTAL TOXICICTY EVALUATION ......................... 35 7. AIM OF THE WORK ................................................................................................................................. 44 8. LEGEND OF ABBREVIATIONS .............................................................................................................. 47 PART 1: PERTURBATION OF THE RETINOIC ACID PATHWAY ............................................................... 48 Introduction .......................................................................................................................................................... 49 Materials and methods ......................................................................................................................................... 51 Results .................................................................................................................................................................... 53 Discussion .............................................................................................................................................................. 57 Tables and Figures ................................................................................................................................................ 61 PART 2: DEVELOPMENT OF AN INTEGRATED SYSTEM BIOLOGY MODEL FOR PREDICTING MIXTURE OF CHEMICALS ACTING ON THE SAME PATHWAY ............................................. 76 Introduction .......................................................................................................................................................... 77 Materials and methods ......................................................................................................................................... 81 Results .................................................................................................................................................................... 86 Discussion .............................................................................................................................................................. 88 Tables and Figures ................................................................................................................................................ 94 PART 3: THE MIXTURE EFFECT OF CO-EXPOSURE TO ETHANOL AND FLUCONAZOLE: A STUDY IN AN ALTERNATIVE DEVELOPMENTAL MODEL, THE ASCIDIAN CIONA INTESTINALIS (AET) .......................................................................................................................... 102 Introduction ........................................................................................................................................................ 103 Materials and methods ....................................................................................................................................... 104 Discussion ............................................................................................................................................................ 109 Tables and Figures .............................................................................................................................................. 111 GENERAL DISCUSSION...................................................................................................................................... 117 ACKNOWLEDGEMENT ...................................................................................................................................... 127 REFERENCES ........................................................................................................................................................ 128 APPENDIX: Papers under review......................................................................................................................... 138 
2009
2009
The morphogenetic events that shape embryonic development rely on a limited set of cell behaviors such as cell rearrangements… 
2003
2003
Members of the GATA family of zinc finger transcription factors have been shown to play important roles in controlling gene… 
1990
1990
Whole-cell and single-channel patch-clamp experiments were performed on unfertilized oocytes of the ascidian Ciona intestinalis…