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GR 138950

Known as: GR-138950, GR138950 
 
National Institutes of Health

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1 relation

Broader (1)

saprisartan potassium

Papers overview

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2011
2011
Renal growth retardation following angiotensin II type 1 (AT₁) receptor antagonism is associated with increased AT₂ receptor protein in fetal sheep.
The actions of angiotensin II on type 1 (AT₁) and type 2 (AT₂) receptor subtypes are important for normal kidney development… Expand
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2008
2008
Evaluation of Direct Transport Pathways of Glycine Receptor Antagonists and an Angiotensin Antagonist from the Nasal Cavity to the Central Nervous System in the Rat Model
PurposeThe aim of this study was to investigate and quantify drug movement to the brain via the neuro-olfactory system after… Expand
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2007
2007
Evaluation of effect of ephedrine on the transport of drugs from the nasal cavity to the systemic circulation and the central nervous system
It has been shown that vasoconstrictive drugs such as ephedrine derivatives are able to decrease systemic absorption of drugs… Expand
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2004
2004
Role of angiotensin II in the pressor response to cortisol in fetal sheep during late gestation.
Glucocorticoids increase blood pressure in utero, but the mechanisms responsible are unclear. This study investigated the… Expand
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2000
2000
Effect of cortisol on blood pressure and the renin-angiotensin system in fetal sheep during late gestation.
The effects of cortisol on blood pressure and the circulating components of the renin-angiotensin system (RAS) were investigated… Expand
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1997
1997
The effect of angiotensin II receptor antagonists on kidney function in two-kidney, two-clip Goldblatt hypertensive rats.
The effect of blockade of the renin-angiotensin system on kidney function using non-peptide angiotensin AT1 receptor antagonists… Expand
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1997
1997
Changes in the maternal and fetal renin-angiotensin systems in response to angiotensin II type 1 receptor blockade and angiotensin-converting enzyme inhibition in pregnant sheep during late gestation…
The effects of maternal administration of either an angiotensin II type 1 (AT1) receptor antagonist (GR138950) or an angiotensin… Expand
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1997
1997
Investigation of the inhibitory effect of N(G)-nitro-L-arginine methyl ester on the antihypertensive effect of the angiotensin AT1 receptor antagonist, GR138950.
1. The effect of systemic administration of the nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME) on… Expand
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1996
1996
Further investigations into the mechanism of the antihypertensive activity of the angiotensin AT1 receptor antagonist, GR138950.
1. The angiotensin AT1 receptor antagonist, GR138950, produces a long-lasting antihypertensive effect in conscious renal artery… Expand
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1994
1994
Bromobenzofuran-based non-peptide antagonists of angiotensin II: GR138950, a potent antihypertensive agent with high oral bioavailability.
We have identified GR138950, a potent antagonist of the angiotensin II receptor with high oral bioavailability, as our second… Expand
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