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G protein-coupled receptors (GPCRs) in the kidney regulate the reabsorption of essential nutrients, ions, and water from the… Expand In multiple sclerosis Oligodendrocytes are obliterated by the immune sys tem. neural s tem/ progenitor cells (NS/P Cs) have the… Expand Progressive myoclonus epilepsies (PMEs) are disorders characterized by myoclonic and generalized seizures with progressive… Expand (GPCRs) are a well-established class of drug target, but several members of this family, so-called orphan GPCRs, remain… Expand Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A–D. Accumulating evidence suggests that PSAP is a… Expand The ‘CoINPocket’ approach identifies pharmacological similarities between G protein–coupled receptors. On the basis of predicted… Expand The N terminus of the receptor GPR37L1 enables constitutive signaling to Gαs. Turning off a constitutively active GPCR In animals… Expand Orphan G protein-coupled receptors (GPCRs) represent a largely untapped resource for the treatment of a variety of diseases… Expand GPR37 (also known as Pael-R) and GPR37L1 are orphan G protein-coupled receptors that are almost exclusively expressed in the… Expand The cloning of a cDNA encoding a G protein‐coupled receptor homologous to the endothelin type B receptor, but unable to bind… Expand