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Background: MK-3475, a humanized monoclonal IgG4 antibody against PD-1, has demonstrated durable antitumor activity in NSCLC and… Expand In the present study, we focused on the molecular events involved in tumor necrosis factor-alpha (TNF-alpha) production in… Expand Abstract In the present study, we characterized the intracellular pathway involved in the macrophage production of tumor necrosis… Expand In this study, we examined the effects of a 105 amino acid carboxyl terminal fragment of β‐amyloid precursor protein (CT105) and… Expand Alzheimer's disease (AD) is characterized by cognitive impairment and excessive deposition of neurite plaques (NPs). Although the… Expand In a brain with Alzheimer's disease (AD), activated glial cells are observed surrounding amyloid plaque. In this study, to… Expand The C-terminal 105 amino acid fragment of beta-amyloid precursor protein (CT105) is highly neurotoxic. To obtain insights into… Expand Abstract: Expression of the carboxyl‐terminal fragment (CT) of the β‐amyloid precursor protein (APP) in transgenic animals has… Expand The effects of beta-amyloid precursor protein (beta-APP) fragments on plasticity of glutamtatergic synaptic transmission were… Expand Abstract: There is mounting evidence that at least some of the neurotoxicity associated with Alzheimer's disease (AD) is due to… Expand