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GO 201

Known as: GO-201, GO201 cpd 
National Institutes of Health

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Peptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
MUC1 intracellular bioactivation mediates lung fibrosis
Background Serum KL6/mucin 1 (MUC1) has been identified as a potential biomarker in idiopathic pulmonary fibrosis (IPF), but the… 
2018
2018
Inhibition of MUC1-C entering nuclear suppresses MYC expression and attenuates malignant growth in esophageal squamous cell carcinoma
Background The mucin 1 (MUC1) heterodimeric protein (N-terminal subunit and C-terminal subunit) is aberrantly overexpressed in… 
2017
2017
Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop
Mucin 1 (MUC1) is a tumor antigen that is aberrantly overexpressed in various cancers, including lung cancer. Our previous in… 
2016
2016
Cigarette Smoke Mediates Nuclear to Cytoplasmic Trafficking of Transcriptional Inhibitor Kaiso through MUC1 and P120-Catenin.
2013
2013
Disrupting BCR-ABL in combination with secondary leukemia-specific pathways in CML cells leads to enhanced apoptosis and decreased proliferation.
Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by expression of the fusion gene BCR-ABL following a… 
2012
2012
MUC1c Regulates Cell Survival in Pancreatic Cancer by Preventing Lysosomal Permeabilization
Background MUC1 is a type I transmembrane glycoprotein aberrantly overexpressed in various cancer cells including pancreatic… 
Highly Cited
2011
Highly Cited
2011
MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory Loop
An inflammatory response of epithelial cells may be co-opted to promote cancer cell survival. Caught in a Loop Mucin 1 (MUC1), a… 
2010
2010
Terminal differentiation of chronic myelogenous leukemia cells is induced by targeting of the MUC1-C oncoprotein
Chronic myelogenous leukemia (CML) is caused by expression of the Bcr-Abl fusion protein in hematopoietic stem cells. The MUC1-C… 
Highly Cited
2009
Highly Cited
2009
Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells.
The mucin 1 (MUC1) oncoprotein is aberrantly overexpressed by approximately 90% of human breast cancers. However, there are no… 
Highly Cited
2009
Highly Cited
2009
MUC1 oncoprotein is a druggable target in human prostate cancer cells
Human prostate cancers are dependent on the androgen receptor for their progression. The MUC1 heterodimeric oncoprotein is… 
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