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GM2-KLH vaccine

Known as: GM2-KLH, GM2-KLH ganglioside, KLH-conjugated GM2 Ganglioside Vaccine 
A cancer vaccine consisting of GM2 ganglioside, a melanoma-specific antigen, conjugated with the immunostimulant keyhole limpet hemocyanin… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
PURPOSE The GM2 ganglioside is an antigen expressed in the majority of melanomas. The GM2-KLH/QS-21 vaccine induces high… Expand
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2010
2010
8505 Background: In the largest adjuvant phase III study in stage II melanoma to date, EORTC 18961 assessed the efficacy and… Expand
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Highly Cited
2001
Highly Cited
2001
PURPOSE Vaccine alternatives to high-dose interferon alfa-2b therapy (HDI), the current standard adjuvant therapy for high-risk… Expand
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Highly Cited
2000
Highly Cited
2000
In a previous randomized Phase III trial (P. O. Livingston et al, J. Clin. Oncol., 12: 1036-1044, 1994), we demonstrated that… Expand
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2000
2000
Immunization with GMK vaccine (G(M2) ganglioside conjugated to keyhole limpet hemocyanin mixed with QS-21 adjuvant) induces anti… Expand
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Review
1998
Review
1998
Gangliosides are neuraminic acid-containing glycosphingolipids that are anchored into the cell membrane lipid bilayer by… Expand
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Highly Cited
1998
Highly Cited
1998
QS-21 is a purified immunological adjuvant derived from a natural source, the bark of the tree Quillaja saponaria. It is a water… Expand
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Highly Cited
1997
Highly Cited
1997
Abstract Natural IgM antibodies against the melanoma cell-surface ganglioside GM2, and IgM antibodies induced by vaccination with… Expand
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Highly Cited
1995
Highly Cited
1995
The cell surface gangliosides GM2, GD2, and GD3 are often overexpressed in malignant melanoma. We have shown previously that… Expand
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Review
1995
Review
1995
Gangliosides are neuraminic acid containing glycosphingolipids that are anchored into the lipid bilayer of the plasma membrane by… Expand
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