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GM2-KLH vaccine
Known as:
GM2-KLH
, GM2-KLH ganglioside
, KLH-conjugated GM2 Ganglioside Vaccine
A cancer vaccine consisting of GM2 ganglioside, a melanoma-specific antigen, conjugated with the immunostimulant keyhole limpet hemocyanin…
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National Institutes of Health
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Related topics
Related topics
1 relation
GM2-KLH vaccine/QS21
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Adjuvant ganglioside GM2-KLH/QS-21 vaccination versus observation after resection of primary tumor > 1.5 mm in patients with stage II melanoma: results of the EORTC 18961 randomized phase III trial.
A. Eggermont
,
S. Suciu
,
+14 authors
A. Spatz
Journal of Clinical Oncology
2013
Corpus ID: 207034579
PURPOSE The GM2 ganglioside is an antigen expressed in the majority of melanomas. The GM2-KLH/QS-21 vaccine induces high…
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2010
2010
Randomized phase III trial comparing postoperative adjuvant ganglioside GM2-KLH/QS-21 vaccination versus observation in stage II (T3-T4N0M0) melanoma: Final results of study EORTC 18961.
A. Eggermont
,
S. Suciu
,
+7 authors
A. Spatz
2010
Corpus ID: 75356456
8505 Background: In the largest adjuvant phase III study in stage II melanoma to date, EORTC 18961 assessed the efficacy and…
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Highly Cited
2001
Highly Cited
2001
High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: results of intergroup…
J. Kirkwood
,
J. Ibrahim
,
+4 authors
U. Rao
Journal of Clinical Oncology
2001
Corpus ID: 12378225
PURPOSE Vaccine alternatives to high-dose interferon alfa-2b therapy (HDI), the current standard adjuvant therapy for high-risk…
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Highly Cited
2000
Highly Cited
2000
Induction of antibodies against GM2 ganglioside by immunizing melanoma patients using GM2-keyhole limpet hemocyanin + QS21 vaccine: a dose-response study.
P. Chapman
,
D. Morrissey
,
+6 authors
P. Livingston
Clinical Cancer Research
2000
Corpus ID: 12397497
In a previous randomized Phase III trial (P. O. Livingston et al, J. Clin. Oncol., 12: 1036-1044, 1994), we demonstrated that…
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Highly Cited
2000
Highly Cited
2000
Vaccination with a bivalent G(M2) and G(D2) ganglioside conjugate vaccine: a trial comparing doses of G(D2)-keyhole limpet hemocyanin.
P. Chapman
,
D. Morrisey
,
+5 authors
P. Livingston
Clinical Cancer Research
2000
Corpus ID: 391146
Immunization with GMK vaccine (G(M2) ganglioside conjugated to keyhole limpet hemocyanin mixed with QS-21 adjuvant) induces anti…
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Review
1998
Review
1998
Ganglioside vaccines with emphasis on GM2.
P. Livingston
Seminars in Oncology
1998
Corpus ID: 42654236
Gangliosides are neuraminic acid-containing glycosphingolipids that are anchored into the cell membrane lipid bilayer by…
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Highly Cited
1998
Highly Cited
1998
QS-21: a water-soluble triterpene glycoside adjuvant.
C. Kensil
,
R. Kammer
Expert Opinion on Investigational Drugs
1998
Corpus ID: 35713140
QS-21 is a purified immunological adjuvant derived from a natural source, the bark of the tree Quillaja saponaria. It is a water…
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Highly Cited
1997
Highly Cited
1997
Tumor cell reactivity mediated by IgM antibodies in sera from melanoma patients vaccinated with GM2 ganglioside covalently linked to KLH is increased by IgG antibodies
Philip S. Livingston
,
Shengle Zhang
,
+5 authors
M. Fleisher
Cancer Immunology and Immunotherapy
1997
Corpus ID: 22914323
Abstract Natural IgM antibodies against the melanoma cell-surface ganglioside GM2, and IgM antibodies induced by vaccination with…
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Highly Cited
1995
Highly Cited
1995
GM2-KLH conjugate vaccine: increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21.
F. Helling
,
S. Zhang
,
+7 authors
P. Livingston
Cancer Research
1995
Corpus ID: 20429447
The cell surface gangliosides GM2, GD2, and GD3 are often overexpressed in malignant melanoma. We have shown previously that…
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Review
1995
Review
1995
Approaches to Augmenting the Immunogenicity of Melanoma Gangliosides: From Whole Melanoma Cells to Ganglioside‐KLH Conjugate Vaccines
Philip S. Livingston
Immunological Reviews
1995
Corpus ID: 45381502
Gangliosides are neuraminic acid containing glycosphingolipids that are anchored into the lipid bilayer of the plasma membrane by…
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