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GKT 136901

Known as: GKT-136901, GKT136901 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Pharmacological characterization of the seven human NOX isoforms and their inhibitors
Background NADPH oxidases (NOX) are a family of flavoenzymes that catalyze the formation of superoxide anion radical (O2•-) and… Expand
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2019
2019
Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation.
Dysfunctional reactive oxygen species (ROS) signaling is considered an important disease mechanism. Therapeutically, non… Expand
Review
2017
Review
2017
Therapeutic potential of NADPH oxidase 1/4 inhibitors
The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is becoming recognized as key modulators of… Expand
2017
2017
NOX4 is an early initiator of neuropathic pain
HighlightsPharmacological NOX4 inhibition is inefficient in later stages of neuropathic pain.Nox4 is upregulated early after… Expand
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2015
2015
IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22(phox) and NOX4 activity in human articular chondrocytes.
OBJECTIVES Osteoarthritis (OA) is characterized by a progressive alteration of the biochemical properties of the articular… Expand
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2015
2015
NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?
Abstract NADPH oxidases (NOXs) represent the only known dedicated source of reactive oxygen species (ROS) and thus a prime… Expand
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2014
2014
The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite.
NADPH oxidases (NOX), catalyzing the reduction of molecular oxygen to form the superoxide radical anion (•O₂⁻) and hydrogen… Expand
Highly Cited
2013
Highly Cited
2013
Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.
Nox (NADPH oxidase)-derived ROS (reactive oxygen species) have been implicated in the development of diabetic nephropathy. Of the… Expand
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Highly Cited
2010
Highly Cited
2010
NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis*
The intracellular signaling events by which NADPH oxidase-generated reactive oxygen species (ROS) modulate vascular smooth muscle… Expand
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Highly Cited
2006
Highly Cited
2006
A comparison of methods for ERP assessment in a P300-based GKT.
P300-based GKT (guilty knowledge test) has been suggested as an alternative approach for conventional polygraphy. The purpose of… Expand
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