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GKT 136901

Known as: GKT-136901, GKT136901 
 

Topic mentions per year

Topic mentions per year

2010-2017
01220102017

Papers overview

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2018
2018
Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells.
BACKGROUND Over-production of reactive oxygen species (ROS) and resulting oxidative stress contribute to retinal damage in… (More)
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2017
2017
NOX4 is an early initiator of neuropathic pain.
Treatment of neuropathic pain remains challenging as the etiology is heterogeneous and pathomechanisms are incompletely… (More)
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Review
2016
Review
2016
NADPH Oxidase 4 at the Nexus of Diabetes, Reactive Oxygen Species, and Renal Metabolism.
  • Eugene Rhee
  • Journal of the American Society of Nephrology…
  • 2016
NADPH oxidases (NOXs) catalyze the transfer of electrons fromNADPH tomolecular oxygen to produce superoxide and/ or hydrogen… (More)
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2015
2015
NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?
NADPH oxidases (NOXs) represent the only known dedicated source of reactive oxygen species (ROS) and thus a prime therapeutic… (More)
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2015
2015
IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22(phox) and NOX4 activity in human articular chondrocytes.
OBJECTIVES Osteoarthritis (OA) is characterized by a progressive alteration of the biochemical properties of the articular… (More)
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2014
2014
The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite.
NADPH oxidases (NOX), catalyzing the reduction of molecular oxygen to form the superoxide radical anion (•O₂⁻) and hydrogen… (More)
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2013
2013
Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.
Nox (NADPH oxidase)-derived ROS (reactive oxygen species) have been implicated in the development of diabetic nephropathy. Of the… (More)
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2011
2011
Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR.
The functional significance and regulation of NAD(P)H oxidase (Nox) isoforms by angiotensin II (Ang II) and endothelin-1 (ET-1… (More)
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2010
2010
NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis.
The intracellular signaling events by which NADPH oxidase-generated reactive oxygen species (ROS) modulate vascular smooth muscle… (More)
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2010
2010
NADPH oxidases regulate CD44 and hyaluronic acid expression
3 The abbreviations used are: ROS, reactive oxygen species; VSMC, vascular smooth muscle cells, HA, hyaluronic acid; DMEM… (More)
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