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GKT 136901

Known as: GKT-136901, GKT136901 
 
National Institutes of Health

Papers overview

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2018
2018
Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells
BACKGROUND Over-production of reactive oxygen species (ROS) and resulting oxidative stress contribute to retinal damage in… Expand
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2018
2018
Hydrogen peroxide derived from NADPH oxidase 4- and 2 contributes to the endothelium-dependent vasodilatation of intrarenal arteries
The role of NADPH oxidase (Nox)-derived reactive oxygen species in kidney vascular function has extensively been investigated in… Expand
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Review
2017
Review
2017
Therapeutic potential of NADPH oxidase 1/4 inhibitors.
The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is becoming recognized as key modulators of… Expand
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2017
2017
NOX4 is an early initiator of neuropathic pain
HighlightsPharmacological NOX4 inhibition is inefficient in later stages of neuropathic pain.Nox4 is upregulated early after… Expand
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2015
2015
NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?
Abstract NADPH oxidases (NOXs) represent the only known dedicated source of reactive oxygen species (ROS) and thus a prime… Expand
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2015
2015
IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22(phox) and NOX4 activity in human articular chondrocytes.
OBJECTIVES Osteoarthritis (OA) is characterized by a progressive alteration of the biochemical properties of the articular… Expand
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Highly Cited
2013
Highly Cited
2013
Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.
Nox (NADPH oxidase)-derived ROS (reactive oxygen species) have been implicated in the development of diabetic nephropathy. Of the… Expand
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Highly Cited
2010
Highly Cited
2010
NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis*
The intracellular signaling events by which NADPH oxidase-generated reactive oxygen species (ROS) modulate vascular smooth muscle… Expand
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2009
2009
Detection of Concealed Information: Combining a Virtual Mock Crime with a P300-based Guilty Knowledge Test
The present study examined the detection of concealed information by combining a virtual mock crime with a P300-based Guilty… Expand
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Highly Cited
2006
Highly Cited
2006
A comparison of methods for ERP assessment in a P300-based GKT.
P300-based GKT (guilty knowledge test) has been suggested as an alternative approach for conventional polygraphy. The purpose of… Expand
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