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GINS1 gene

Known as: GINS1, GINS COMPLEX, KIAA0186 
National Institutes of Health

Related topics

Related topics

1 relation
GINS complex location

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Anlotinib inhibits synovial sarcoma by targeting GINS1: a novel downstream target oncogene in progression of synovial sarcoma
BackgroundSynovial sarcoma (SS) is an aggressive soft-tissue sarcoma with a poor prognosis owing to its resistance to radiation… 
Highly Cited
2017
Highly Cited
2017
Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency
Inborn errors of DNA repair or replication underlie a variety of clinical phenotypes. We studied 5 patients from 4 kindreds, all… 
2017
2017
The Cdc45/RecJ-like protein forms a complex with GINS and MCM, and is important for DNA replication in Thermococcus kodakarensis
Abstract The archaeal minichromosome maintenance (MCM) has DNA helicase activity, which is stimulated by GINS in several archaea… 
Highly Cited
2016
Highly Cited
2016
Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate
The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during the elongation step of eukaryotic genome duplication and this process… 
Highly Cited
2016
Highly Cited
2016
Structure of human Cdc45 and implications for CMG helicase function
Cell division cycle protein 45 (Cdc45) is required for DNA synthesis during genome duplication, as a component of the Cdc45-MCM… 
Highly Cited
2015
Highly Cited
2015
Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex*
Mcm10 is required for the initiation of eukaryotic DNA replication and contributes in some unknown way to the activation of the… 
2015
2015
Fidelity consequences of the impaired interaction between DNA polymerase epsilon and the GINS complex.
Highly Cited
2011
Highly Cited
2011
MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract*
In late mitosis and G1, Mcm2-7 are assembled onto replication origins to license them for initiation in the upcoming S phase… 
2011
2011
Architectures of archaeal GINS complexes, essential DNA replication initiation factors
BackgroundIn the early stage of eukaryotic DNA replication, the template DNA is unwound by the MCM helicase, which is activated… 
Highly Cited
2005
Highly Cited
2005
PSF1 Is Essential for Early Embryogenesis in Mice
ABSTRACT Psf1 (partner of sld five 1) forms a novel heterotetramer complex, GINS (Go, Ichi, Nii, and San; five, one, two, and… 
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