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Gid4, a subunit of the ubiquitin ligase GID, is the recognition component of the Pro/N-degron pathway. Gid4 targets proteins in… Expand Significance In eukaryotes, N-degron pathways comprise proteolytic systems whose unifying feature is their ability to recognize… Expand BackgroundHigh-temperature fermentation is desirable for the industrial production of ethanol, which requires thermotolerant… Expand The pro/N‐degron pathway is an evolved protein degradation pathway through the ubiquitin‐proteasome system. It is a vital pathway… Expand Gluconeogenesis, the reverse process of glycolysis, is a favorable mechanism at conditions of glucose deprivation. Pck1 is a rate… Expand The N-end rule pathway senses the N-terminal destabilizing residues of degradation substrates for the ubiquitin-proteasome system… Expand Glucose consumption via glycolysis and its biosynthesis via gluconeogenesis are central reciprocal pathways controlled by a set… Expand How to remove unnecessary enzymes The terminal amino acid of proteins can determine their longevity. Chen et al. now delineate a… Expand Malate in sake (a Japanese alcoholic beverage) is an important component for taste that is produced by yeasts during alcoholic… Expand When Saccharomyces cerevisiae is starved of glucose, the gluconeogenic enzymes fructose-1,6-bisphosphatase (FBPase), malate… Expand