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GI 147211

Known as: GI-147211, GI147211 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2017
02419952017

Related topics

Related topics

2 relations
OSI 211

Broader (1)

lurtotecan

Related mentions per year

Related mentions per year

1995-2017
1990200020102020
GI 147211
lurtotecan
OSI 211

Papers overview

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2000
2000
Activity and toxicity of GI147211 in breast, colorectal and non-small-cell lung cancer patients: an EORTC-ECSG phase II clinical study.
BACKGROUND GI147211 is a water-soluble synthetic analogue of camptothecin showing promising in vivo and in vitro antitumor… (More)
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2000
2000
Liposomal lurtotecan (NX211): determination of total drug levels in human plasma and urine by reversed-phase high-performance liquid chromatography.
Lurtotecan (GI147211; LRT) is a semisynthetic and water-soluble analogue of the topoisomerase I inhibitor camptothecin. To… (More)
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1998
1998
Potent and broad antitumor effects of DX-8951f, a water-soluble camptothecin derivative, against various human tumors xenografted in nude mice
Purpose: We have previously reported that DX-8951f, a water-soluble and nonprodrug camptothecin (CPT) derivative, exhibits both… (More)
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1998
1998
Phase I and pharmacokinetic study of GI147211, a water-soluble camptothecin analogue, administered for five consecutive days every three weeks.
GI1147211 is a 7-substituted 10,11-ethylenedioxy-20(S)-camptothecin analogue that inhibits the nuclear enzyme topoisomerase I. In… (More)
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1997
1997
Simple and versatile high-performance liquid chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of camptothecin anticancer drugs.
The well documented hydrolysis of the alpha-hydroxy-delta-lactone ring moiety in camptothecin and related analogues is routinely… (More)
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1997
1997
Topoisomerase I Inhibitors.
Topoisomerase I inhibitors are a new class of anticancer agents with a mechanism of action aimed at interrupting DNA replication… (More)
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1997
1997
The bioavailability of oral GI147211 (GG211), a new topoisomerase I inhibitor.
Topoisomerase I inhibitors are new compounds of interest for cancer chemotherapy. We performed a study with GI147211, a new… (More)
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1996
1996
Phase I and pharmacological study of the new topoisomerase I inhibitor GI147211, using a daily x 5 intravenous administration.
Topoisomerase I inhibitors are interesting anti-cancer agents with a novel mechanism of action. We performed a phase I study with… (More)
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1996
1996
Identification and characterization of the sulfate precipitate in GI147211C IV formulation.
GI147211, a water soluble analog of camptothecin, is currently being investigated for the treatment of cancer as a topoisomerase… (More)
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1995
1995
In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues.
The development of camptothecin-like compounds as inhibitors of topoisomerase I for the treatment of resistant tumors has… (More)
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