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GI 147211

Known as: GI-147211, GI147211 
 
National Institutes of Health

Papers overview

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2000
2000
BACKGROUND GI147211 is a water-soluble synthetic analogue of camptothecin showing promising in vivo and in vitro antitumor… Expand
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2000
2000
BACKGROUND GI147211, a 10,11-ethylenedioxy substituted analogue of camptothecin (CPT), was brought into clinical development… Expand
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2000
2000
Lurtotecan (GI147211; LRT) is a semisynthetic and water-soluble analogue of the topoisomerase I inhibitor camptothecin. To… Expand
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Review
1998
Review
1998
The camptothecin topoisomerase I-targeting agents are new class of antitumor drugs with demonstrated clinical activity in human… Expand
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1998
1998
Purpose: We have previously reported that DX-8951f, a water-soluble and nonprodrug camptothecin (CPT) derivative, exhibits both… Expand
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1998
1998
GI1147211 is a 7-substituted 10,11-ethylenedioxy-20(S)-camptothecin analogue that inhibits the nuclear enzyme topoisomerase I. In… Expand
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1997
1997
The well documented hydrolysis of the alpha-hydroxy-delta-lactone ring moiety in camptothecin and related analogues is routinely… Expand
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1996
1996
Topoisomerase I inhibitors are interesting anti-cancer agents with a novel mechanism of action. We performed a phase I study with… Expand
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1995
1995
A sensitive reversed-phase high-performance liquid chromatographic method has been developed and validated for the quantitation… Expand
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1995
1995
The development of camptothecin-like compounds as inhibitors of topoisomerase I for the treatment of resistant tumors has… Expand
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